Indoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory T cells

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dc.contributor.authorT J Yun-
dc.contributor.authorJ S Lee-
dc.contributor.authorK Machmach-
dc.contributor.authorD Shim-
dc.contributor.authorJ Choi-
dc.contributor.authorY J Wi-
dc.contributor.authorH S Jang-
dc.contributor.authorI H Jung-
dc.contributor.authorK Kim-
dc.contributor.authorWoon Kee Yoon-
dc.contributor.authorM A Miah-
dc.contributor.authorB Li-
dc.contributor.authorJ Chang-
dc.contributor.authorM G Bego-
dc.contributor.authorT N Q Pham-
dc.contributor.authorJ Loschko-
dc.contributor.authorJ H Fritz-
dc.contributor.authorA B Krug-
dc.contributor.authorS P Lee-
dc.contributor.authorT Keler-
dc.contributor.authorJ V Guimond-
dc.contributor.authorE Haddad-
dc.contributor.authorE A Cohen-
dc.contributor.authorM G Sirois-
dc.contributor.authorI El-Hamamsy-
dc.contributor.authorM Colonna-
dc.contributor.authorG T Oh-
dc.contributor.authorJ H Choi-
dc.contributor.authorC Cheong-
dc.date.accessioned2017-04-19T10:22:17Z-
dc.date.available2017-04-19T10:22:17Z-
dc.date.issued2016-
dc.identifier.issn15504131-
dc.identifier.uri10.1016/j.cmet.2016.04.010ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13271-
dc.description.abstractPlasmacytoid dendritic cells (pDCs) are unique bone-marrow-derived cells that produce large amounts of type I interferon in response to microbial stimulation. Furthermore, pDCs also promote T cell tolerance in sterile-inflammation conditions. However, the immunomodulatory role of aortic pDCs in atherosclerosis has been poorly understood. Here, we identified functional mouse and human pDCs in the aortic intima and showed that selective, inducible pDC depletion in mice exacerbates atherosclerosis. Aortic pDCs expressed CCR9 and indoleamine 2,3-dioxygenase 1 (IDO-1), an enzyme involved in driving the generation of regulatory T cells (Tregs). As a consequence, loss of pDCs resulted in decreased numbers of Tregs and reduced IL-10 levels in the aorta. Moreover, antigen presentation by pDCs expanded antigen-specific Tregs in the atherosclerotic aorta. Notably, Tregs ablation affected pDC homeostasis in diseased aorta. Accordingly, pDCs in human atherosclerotic aortas colocalized with Tregs. Collectively, we identified a mechanism of atheroprotection mediated by tolerogenic aortic pDCs.-
dc.publisherElsevier-Cell Press-
dc.titleIndoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory T cells-
dc.title.alternativeIndoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory T cells-
dc.typeArticle-
dc.citation.titleCell Metabolism-
dc.citation.number5-
dc.citation.endPage866-
dc.citation.startPage852-
dc.citation.volume23-
dc.contributor.affiliatedAuthorWoon Kee Yoon-
dc.contributor.alternativeName윤태진-
dc.contributor.alternativeName이준성-
dc.contributor.alternativeNameMachmach-
dc.contributor.alternativeName심다희-
dc.contributor.alternativeName최준희-
dc.contributor.alternativeName위영진-
dc.contributor.alternativeName장형석-
dc.contributor.alternativeName정인혁-
dc.contributor.alternativeName김경대-
dc.contributor.alternativeName윤원기-
dc.contributor.alternativeNameMiah-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeName장진삼-
dc.contributor.alternativeNameBego-
dc.contributor.alternativeNamePham-
dc.contributor.alternativeNameLoschko-
dc.contributor.alternativeNameFritz-
dc.contributor.alternativeNameKrug-
dc.contributor.alternativeName이승표-
dc.contributor.alternativeNameKeler-
dc.contributor.alternativeNameGuimond-
dc.contributor.alternativeNameHaddad-
dc.contributor.alternativeNameCohen-
dc.contributor.alternativeNameSirois-
dc.contributor.alternativeNameEl-Hamamsy-
dc.contributor.alternativeNameColonna-
dc.contributor.alternativeName오구택-
dc.contributor.alternativeName최재훈-
dc.contributor.alternativeNameCheong-
dc.identifier.bibliographicCitationCell Metabolism, vol. 23, no. 5, pp. 852-866-
dc.identifier.doi10.1016/j.cmet.2016.04.010-
dc.description.journalClassY-
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Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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