Ingenane-type diterpene compounds from Euphorbia kansui modulate IFN-? production through NF-?B activation

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Title
Ingenane-type diterpene compounds from Euphorbia kansui modulate IFN-? production through NF-?B activation
Author(s)
Sehyun Oh; Hyun Woo Oh; Ha-Reum Lee; S Y Yoon; Sei-Ryang Oh; Young-Eun Go; Nina Yoo; Jinseon Jeong; Jae Wha Kim
Bibliographic Citation
Journal of Science of Food and Agriculture, vol. 96, no. 8, pp. 2635-2640
Publication Year
2016
Abstract
BACKGROUND: Euphorbia kansui, a traditional medical herb, has been shown to have anti-tumour and anti-viral activities. Previously, we have reported that E. kansui increases interferon-gamma (IFN-γ) production in natural killer (NK) cells. However, it is not clear how E. kansui regulates IFN-γ secretion by NK cells. RESULTS: In this study, E. kansui was separated into six individual compounds from the same chloroform fraction so that the activity of each compound could be compared. E. kansui compounds induced IFN-γ secretion through the phosphorylation of protein kinase D and IκB kinase pathways. Furthermore, E. kansui compounds activated the translocation of p65, a sub-unit of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), to the nucleus and induced NF-κB at the transcriptional level. CONCLUSION: These findings suggest that E. kansui enhances IFN-γ secretion through the NF-κB pathway in NK cells.
Keyword
Euphorbia kansuiIFN-gammaNF-κBNK cells
ISSN
0022-5142
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/jsfa.7380
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Facility Management Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Division of Biomaterials Research > Cell Factory Research Center > 1. Journal Articles
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