DC Field | Value | Language |
---|---|---|
dc.contributor.author | Su-Jin Baek | - |
dc.contributor.author | Mirang Kim | - |
dc.contributor.author | Dong-Hyuck Bae | - |
dc.contributor.author | Jeong-Hwan Kim | - |
dc.contributor.author | Hee-Jin Kim | - |
dc.contributor.author | M E Han | - |
dc.contributor.author | S O Oh | - |
dc.contributor.author | Yong Sung Kim | - |
dc.contributor.author | Seon-Young Kim | - |
dc.date.accessioned | 2017-04-19T10:22:36Z | - |
dc.date.available | 2017-04-19T10:22:36Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | 10.18632/oncotarget.8239 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13283 | - |
dc.description.abstract | Abnormal DNA methylation is an epigenetic mechanism that promotes gastric carcinogenesis. While the abnormal methylation at promoter regions has been characterized for many genes, the function of DNA methylation marks at distal regulatory regions in gastric cancer remains poorly described. Here, we performed RNA-seq, MBD-seq, and H3K27ac ChIP-seq on gastric tissues and cell lines to understand the epigenetic changes in the distal as well as the proximal regulatory regions. In total, 257,651 significant DMRs (Differentially methylated regions) were identified in gastric cancer, and the majority of these DMRs were located in the intergenic, intronic, and non-coding RNA regions. We identified the aberrant expression of many genes and lncRNAs due to changes in DNA methylation. Furthermore, we profiled the molecular subtype-specific methylation patterns in gastric cancer to characterize subtype-specific regulators that undergo DNA methylation changes. Our findings provide insights for understanding methylation changes at distal regulatory regions and reveal novel epigenetic targets in gastric cancer. | - |
dc.publisher | Impact Journals | ko |
dc.title | Integrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer | - |
dc.title.alternative | Integrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer | - |
dc.type | Article | - |
dc.citation.title | Oncotarget | - |
dc.citation.number | 18 | - |
dc.citation.endPage | 25631 | - |
dc.citation.startPage | 25620 | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Su-Jin Baek | - |
dc.contributor.affiliatedAuthor | Mirang Kim | - |
dc.contributor.affiliatedAuthor | Dong-Hyuck Bae | - |
dc.contributor.affiliatedAuthor | Jeong-Hwan Kim | - |
dc.contributor.affiliatedAuthor | Hee-Jin Kim | - |
dc.contributor.affiliatedAuthor | Yong Sung Kim | - |
dc.contributor.affiliatedAuthor | Seon-Young Kim | - |
dc.contributor.alternativeName | 백수진 | - |
dc.contributor.alternativeName | 김미랑 | - |
dc.contributor.alternativeName | 배동혁 | - |
dc.contributor.alternativeName | 김정환 | - |
dc.contributor.alternativeName | 김희진 | - |
dc.contributor.alternativeName | 한명은 | - |
dc.contributor.alternativeName | 오새옥 | - |
dc.contributor.alternativeName | 김용성 | - |
dc.contributor.alternativeName | 김선영 | - |
dc.identifier.bibliographicCitation | Oncotarget, vol. 7, no. 18, pp. 25620-25631 | - |
dc.identifier.doi | 10.18632/oncotarget.8239 | - |
dc.subject.keyword | DNA methylation | - |
dc.subject.keyword | Enhancer | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | LncRNAs | - |
dc.subject.keyword | Promoter | - |
dc.subject.local | DNA methylation | - |
dc.subject.local | DNAmethylation | - |
dc.subject.local | enhancer | - |
dc.subject.local | Enhancer | - |
dc.subject.local | gastric cancer | - |
dc.subject.local | Gastric cancer (GC) | - |
dc.subject.local | Gastric cancer | - |
dc.subject.local | LncRNAs | - |
dc.subject.local | Promoter | - |
dc.subject.local | promoter | - |
dc.subject.local | Promoters | - |
dc.description.journalClass | N | - |
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