Integrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer

Cited 13 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorSu-Jin Baek-
dc.contributor.authorMirang Kim-
dc.contributor.authorDong-Hyuck Bae-
dc.contributor.authorJeong-Hwan Kim-
dc.contributor.authorHee-Jin Kim-
dc.contributor.authorM E Han-
dc.contributor.authorS O Oh-
dc.contributor.authorYong Sung Kim-
dc.contributor.authorSeon-Young Kim-
dc.date.accessioned2017-04-19T10:22:36Z-
dc.date.available2017-04-19T10:22:36Z-
dc.date.issued2016-
dc.identifier.issn1949-2553-
dc.identifier.uri10.18632/oncotarget.8239ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13283-
dc.description.abstractAbnormal DNA methylation is an epigenetic mechanism that promotes gastric carcinogenesis. While the abnormal methylation at promoter regions has been characterized for many genes, the function of DNA methylation marks at distal regulatory regions in gastric cancer remains poorly described. Here, we performed RNA-seq, MBD-seq, and H3K27ac ChIP-seq on gastric tissues and cell lines to understand the epigenetic changes in the distal as well as the proximal regulatory regions. In total, 257,651 significant DMRs (Differentially methylated regions) were identified in gastric cancer, and the majority of these DMRs were located in the intergenic, intronic, and non-coding RNA regions. We identified the aberrant expression of many genes and lncRNAs due to changes in DNA methylation. Furthermore, we profiled the molecular subtype-specific methylation patterns in gastric cancer to characterize subtype-specific regulators that undergo DNA methylation changes. Our findings provide insights for understanding methylation changes at distal regulatory regions and reveal novel epigenetic targets in gastric cancer.-
dc.publisherImpact Journalsko
dc.titleIntegrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer-
dc.title.alternativeIntegrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer-
dc.typeArticle-
dc.citation.titleOncotarget-
dc.citation.number18-
dc.citation.endPage25631-
dc.citation.startPage25620-
dc.citation.volume7-
dc.contributor.affiliatedAuthorSu-Jin Baek-
dc.contributor.affiliatedAuthorMirang Kim-
dc.contributor.affiliatedAuthorDong-Hyuck Bae-
dc.contributor.affiliatedAuthorJeong-Hwan Kim-
dc.contributor.affiliatedAuthorHee-Jin Kim-
dc.contributor.affiliatedAuthorYong Sung Kim-
dc.contributor.affiliatedAuthorSeon-Young Kim-
dc.contributor.alternativeName백수진-
dc.contributor.alternativeName김미랑-
dc.contributor.alternativeName배동혁-
dc.contributor.alternativeName김정환-
dc.contributor.alternativeName김희진-
dc.contributor.alternativeName한명은-
dc.contributor.alternativeName오새옥-
dc.contributor.alternativeName김용성-
dc.contributor.alternativeName김선영-
dc.identifier.bibliographicCitationOncotarget, vol. 7, no. 18, pp. 25620-25631-
dc.identifier.doi10.18632/oncotarget.8239-
dc.subject.keywordDNA methylation-
dc.subject.keywordEnhancer-
dc.subject.keywordGastric cancer-
dc.subject.keywordLncRNAs-
dc.subject.keywordPromoter-
dc.subject.localDNA methylation-
dc.subject.localDNAmethylation-
dc.subject.localenhancer-
dc.subject.localEnhancer-
dc.subject.localgastric cancer-
dc.subject.localGastric cancer (GC)-
dc.subject.localGastric cancer-
dc.subject.localLncRNAs-
dc.subject.localPromoter-
dc.subject.localpromoter-
dc.subject.localPromoters-
dc.description.journalClassN-
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.