Metal oxide semiconductor field-effect transistor (MOSFET)-based direct monitoring of p53 in spiked serum

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Title
Metal oxide semiconductor field-effect transistor (MOSFET)-based direct monitoring of p53 in spiked serum
Author(s)
Yoonkwang Oh; T T Dung; Y Lee; Chang-Soo LeeMoonil Kim
Bibliographic Citation
Journal of Industrial and Engineering Chemistry, vol. 37, pp. 95-100
Publication Year
2016
Abstract
We describe the direct monitoring of p53 in a human serum sample by a metal oxide semiconductor field-effect transistor (MOSFET) biosensor. The biomolecular interaction between DNA and p53 protein was measured using a DNA-modified MOSFET under the condition of physiological ionic strength. Treated with p53 in serum, a MOSFET exhibited a comparable change in the drain current, while no alteration in response to serum spiked with DNA binding-defective p53 was observed, leading to a good agreement between theory and experiment. Our data suggest that a MOSFET device can be potentially used for the determination of p53 in serum samples on the basis of DNA-protein interaction.
Keyword
BiosensorMOSFETP53SerumTumor suppressor
ISSN
1226-086X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jiec.2016.03.015
Type
Article
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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