Human neural stem cells overexpressing a carboxylesterase inhibit bladder tumor growth = 카르복실에스테레이즈를 과발현하는 인간 신경줄기세포의 방광암 성장억제 효과

Cited 3 time in scopus
Metadata Downloads
Title
Human neural stem cells overexpressing a carboxylesterase inhibit bladder tumor growth = 카르복실에스테레이즈를 과발현하는 인간 신경줄기세포의 방광암 성장억제 효과
Author(s)
S S Choi; B H Chi; I H Chang; K D Kim; Sang-Rae Lee; S U Kim; H J Lee
Bibliographic Citation
Molecular Cancer Therapeutics, vol. 15, no. 6, pp. 1201-1207
Publication Year
2016
Abstract
Bladder cancer is a significant clinical and economic problem. Despite intravesical chemotherapy and immunotherapy, up to 80% of patients with non-muscle-invasive bladder cancer develop recurrent tumors, of which 20% to 30% evolve into more aggressive, potentially lethal tumors. Recently, bladder cancer cells are considered to be mediators of resistance to current therapies and therefore represent strong candidates as biologic targets. No effective chemotherapy has yet been developed for advanced bladder cancer. It is desirable that a drug can be delivered directly and specifically to bladder cancer cells. Stem cells have selective migration ability toward cancer cells, and therapeutic genes can be easily transduced into stem cells. In suicide gene therapy for cancer, stem cells carry a gene encoding a carboxylesterase (CE) enzyme that transforms an inert CPT-11 prodrug into a toxic SN-38 product, a topoisomerase 1 inhibitor. In immunodeficient mice, systemically transplanted HB1.F3.CE stem cells migrated toward the tumor implanted by the TCCSUP bladder cancer cell line, and, in combination with CPT-11, the volume of tumors was significantly reduced. These findings may contribute to the development of a new selective chemotherapeutic strategy against bladder cancer.
ISSN
1535-7163
Publisher
Amer Assoc Cancer Research
DOI
http://dx.doi.org/10.1158/1535-7163.MCT-15-0636
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.