Phenylacylphenol derivatives with anti-melanogenic activity from Stewartia pseudocamellia

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Title
Phenylacylphenol derivatives with anti-melanogenic activity from Stewartia pseudocamellia
Author(s)
Zuh Kyung Seong; H S Kim; Yu Mi Won; Jae Lim Kim; Hyuk-Hwan Song; Doo-Young KimSei-Ryang Oh; H W Cho; J H Cho; Hyeong Kyu Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 39, no. 5, pp. 636-645
Publication Year
2016
Abstract
Three new phenylacylphenol derivatives, stewartianol (1), deoxystewartianol-4′-O-arabinoglucoside (2), and stewartianol-3-O-glucoside (3), along with nine known compounds, methylesculin (4), fraxoside (5), fraxetin (6), scopletin (7), (+)-dihydromyricetin (8), (+)-taxifolin-7-O-β-d-glucose (9), (+)-taxifolin (10), (+)-dihydrokaempferol-7-O-β-d-glucose (11), and 3-acetyl-ursolic acid (12), were isolated from the twigs of Stewartia pseudocamellia; commonly used as folk medicine in Korea. The structures of the isolated compounds were identified using spectroscopic analysis, including 1D, 2D NMR, MS and compared with published data. The compounds were tested for their anti-melanogenic activity in cultured murine B16 melanoma cells. Stewartianol (1) and stewartianol-3-O-glucoside (3) showed an inhibitory effect significantly on melanogenesis in a concentration-dependent manner.
Keyword
MelanogenesisMurine B16 melanoma cellsPhenylacylphenolAnti-melanogenic activityStewartia pseudocamellica
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-016-0717-9
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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