(p40)2-Fc reduces immune-inflammatory response through the activation of T cells in collagen induced arthritis mice

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Title
(p40)2-Fc reduces immune-inflammatory response through the activation of T cells in collagen induced arthritis mice
Author(s)
S Y Lee; S H Lee; S J Park; Doo-Jin Kim; E K Kim; J K Kim; S H Yang; S H Park; Y C Sung; H Y Kim; M L Cho
Bibliographic Citation
Immunology Letters, vol. 176, pp. 36-43
Publication Year
2016
Abstract
IL-12p40 homodimer, a natural antagonist of IL-12 and IL-23, performs an important role in the expression of proinflammatory cytokines that is essential for Th1 and Th17 immune responses. Here, we reveal the therapeutic and immunosuppressive effect of the IL-12p40 subunit ((p40)2-Fc) in an experimental autoimmune arthritis model. We hypothesized that (p40)2-Fc may reduce the inflammatory response and the activation of T cells. In this study, we intraperitoneally injected (p40)2-Fc into collagen induced arthritis (CIA) mice to identify whether (p40)2-Fc attenuates CIA severity. (p40)2-Fc reduced the development of CIA, joint inflammation and cartilage destruction. (p40)2-Fc also significantly decreased the concentration of serum immunoglobulin as well as the number of T cells and C II specific T cells. In addition, osteoclastogenesis in (p40)2-Fc treated mice was down-regulated compared to the mice treated with (p40)2-Fc control. We observed that (p40)2-Fc treatment alleviates arthritis in mice with CIA, reducing inflammation and osteoclast differentiation. These findings suggest that (p40)2-Fc can be a potential therapeutic approach for autoimmune arthritis.
Keyword
(p40)2-FcOsteoclastogenesisRheumatoid arthritis
ISSN
0165-2478
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.imlet.2016.05.013
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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