Cytokine-induced killer cells interact with tumor lysate-pulsed dendritic cells via CCR5 signaling

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dc.contributor.authorH K Lee-
dc.contributor.authorY G Kim-
dc.contributor.authorJ S Kim-
dc.contributor.authorE J Park-
dc.contributor.authorB Kim-
dc.contributor.authorKi Hwan Park-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorJ T Hong-
dc.contributor.authorY Kim-
dc.contributor.authorS B Han-
dc.date.accessioned2017-04-19T10:24:51Z-
dc.date.available2017-04-19T10:24:51Z-
dc.date.issued2016-
dc.identifier.issn0304-3835-
dc.identifier.uri10.1016/j.canlet.2016.05.020ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13340-
dc.description.abstractThe antitumor activity of cytokine-induced killer (CIK) cells can be increased by co-culturing them with tumor lysate-pulsed dendritic cells (tDCs); this phenomenon has been studied mainly at the population level. Using time-lapse imaging, we examined how CIK cells gather information from tDCs at the single-cell level. tDCs highly expressed CCL5, which bound CCR5 expressed on CIK cells. tDCs strongly induced migration of Ccr5+/+ CIK cells, but not that of Ccr5(-/-) CIK cells or Ccr5+/+ CIK cells treated with the CCR5 antagonist Maraviroc. Individual tDCs contacted Ccr5+/+ CIK cells more frequently and lengthily than with Ccr5(-/-) CIK cells. Consequently, tDCs increased the antitumor activity of Ccr5+/+ CIK cells in vitro and in vivo, but did not increase that of Ccr5(-/-) CIK cells. Taken together, our data provide insight into the mechanism of CIK cell activation by tDCs at the single-cell level.-
dc.publisherElsevier-
dc.titleCytokine-induced killer cells interact with tumor lysate-pulsed dendritic cells via CCR5 signaling-
dc.title.alternativeCytokine-induced killer cells interact with tumor lysate-pulsed dendritic cells via CCR5 signaling-
dc.typeArticle-
dc.citation.titleCancer Letters-
dc.citation.number2-
dc.citation.endPage149-
dc.citation.startPage142-
dc.citation.volume378-
dc.contributor.affiliatedAuthorKi Hwan Park-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName이홍경-
dc.contributor.alternativeName김용국-
dc.contributor.alternativeName김지성-
dc.contributor.alternativeName박은재-
dc.contributor.alternativeName김보영-
dc.contributor.alternativeName박기환-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName홍진태-
dc.contributor.alternativeName김영수-
dc.contributor.alternativeName한상배-
dc.identifier.bibliographicCitationCancer Letters, vol. 378, no. 2, pp. 142-149-
dc.identifier.doi10.1016/j.canlet.2016.05.020-
dc.subject.keywordCellcell interaction-
dc.subject.keywordMigration-
dc.subject.keywordTime-lapse imaging-
dc.subject.localCellcell interaction-
dc.subject.localmigration-
dc.subject.localMigration-
dc.subject.localTime-lapse imaging-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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