Lanostane triterpenes isolated from Antrodia heteromorpha and their inhibitory effects on RANKL-induced osteoclastogenesis

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Title
Lanostane triterpenes isolated from Antrodia heteromorpha and their inhibitory effects on RANKL-induced osteoclastogenesis
Author(s)
J Kwon; H Lee; Yeo Dae Yoon; B Y Hwang; Y Guo; Jong Soon Kang; J J Kim; D Lee
Bibliographic Citation
Journal of Natural Products, vol. 79, no. 6, pp. 1689-1693
Publication Year
2016
Abstract
Two new spiro-lanostane triterpenoids, antrolactones A and B (1 and 2), along with polyporenic acid C (3), were isolated from an EtOAc-soluble extract of Antrodia heteromorpha culture medium, and the chemical structures of the new compounds were elucidated by application of NMR, MS, and ECD spectroscopic techniques. All isolated compounds exhibited inhibitory effects on receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.jnatprod.6b00207
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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