Differential matrix metalloprotease (MMP) expression profiles found in aged gingiva

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dc.contributor.authorS Kim-
dc.contributor.authorS H Ahn-
dc.contributor.authorJ S Lee-
dc.contributor.authorJ E Song-
dc.contributor.authorS H Cho-
dc.contributor.authorS Jung-
dc.contributor.authorSeon-Kyu Kim-
dc.contributor.authorSeok Ho Kim-
dc.contributor.authorKwang-Pyo Lee-
dc.contributor.authorKi Sun Kwon-
dc.contributor.authorT H Lee-
dc.date.accessioned2017-04-19T10:24:57Z-
dc.date.available2017-04-19T10:24:57Z-
dc.date.issued2016-
dc.identifier.issn19326203-
dc.identifier.uri10.1371/journal.pone.0158777ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13345-
dc.description.abstractThe periodontium undergoes age-related cellular and clinical changes, but the involved genes are not yet known. Here, we investigated age-related genetic changes in gingiva at the transcriptomic level. Genes that were differentially expressed between young and old human gingiva were identified by RNA sequencing and verified by real-time PCR. A total of 1939 mRNA transcripts showed significantly differential expression between young and old gingival tissues. Matrix metalloprotease (MMP) regulation was the top pathway involved in gingival aging. MMP3, MMP9, MMP12, and MMP13 were upregulated in old gingival tissues, concomitantly with interleukin-1 beta (IL1B) expression. In vitro experiments using human gingival fibroblasts (hGFs) showed that MMP12 was upregulated in old hGFs compared to young hGFs. Moreover, the MMP3, MMP9 and IL1B levels were more highly stimulated by infection with the oral bacterium, Fusobacterium nucleatum, in old hGFs compared to young hGFs. Collectively, these findings suggest that, in gingiva, the upregulation of MMP12 may be a molecular hallmark of natural aging, while the upregulations of MMP3, MMM9, and IL1B may indicate externally (e.g., infection)-induced aging. These findings contribute to our understanding of the molecular targets involved in gingival aging.-
dc.publisherPublic Library of Science-
dc.titleDifferential matrix metalloprotease (MMP) expression profiles found in aged gingiva-
dc.title.alternativeDifferential matrix metalloprotease (MMP) expression profiles found in aged gingiva-
dc.typeArticle-
dc.citation.titlePLoS One-
dc.citation.number7-
dc.citation.endPagee0158777-
dc.citation.startPagee0158777-
dc.citation.volume11-
dc.contributor.affiliatedAuthorSeon-Kyu Kim-
dc.contributor.affiliatedAuthorKwang-Pyo Lee-
dc.contributor.affiliatedAuthorKi Sun Kwon-
dc.contributor.alternativeName김수희-
dc.contributor.alternativeName안선희-
dc.contributor.alternativeName이진실-
dc.contributor.alternativeName송지은-
dc.contributor.alternativeName조성현-
dc.contributor.alternativeName정승건-
dc.contributor.alternativeName김선규-
dc.contributor.alternativeName김석호-
dc.contributor.alternativeName이광표-
dc.contributor.alternativeName권기선-
dc.contributor.alternativeName이태훈-
dc.identifier.bibliographicCitationPLoS One, vol. 11, no. 7, pp. e0158777-e0158777-
dc.identifier.doi10.1371/journal.pone.0158777-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
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