Appearance of osteoporosis in rat experimental autoimmune encephalomyelitis

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Title
Appearance of osteoporosis in rat experimental autoimmune encephalomyelitis
Author(s)
M Ahn; S Kang; C Park; J Kim; Kyungsook Jung; M Yang; S H Kim; C Moon; T Shin
Bibliographic Citation
Korean Journal of Veterinary Research, vol. 56, no. 2, pp. 117-120
Publication Year
2016
Abstract
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by transient paralysis followed by recovery. To evaluate whether transient paralysis in EAE affects bone density, tibiae of EAE rats were morphologically investigated using micro-computed tomography and histology. The parameters of bone health were significantly reduced at the peak stage of EAE rats relative to those of controls (p < 0.05). The reduction of bone density was found to remain unchanged, even in the recovery stage. Collectively, the present data suggest that osteoporosis occurs in paralytic rats with monophasic EAE, possibly through the disuse of hindlimbs and/or autoimmune inflammation.
Keyword
AutoimmunityExperimental autoimmune encephalomyelitisMicro-computed tomographyOsteoporosis
ISSN
1225-0198
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.14405/kjvr.2016.56.2.117
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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