Anti-obesity effects of spiramycin in vitro and in vivo

Cited 7 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorMun-Ock Kim-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorJi Hee Choi-
dc.contributor.authorTae Hyun Son-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorHeung Joo Yuk-
dc.contributor.authorSungchan Cho-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorChang Woo Lee-
dc.contributor.authorJinhyuk Lee-
dc.contributor.authorC K Lee-
dc.contributor.authorS T Hong-
dc.contributor.authorSu Ui Lee-
dc.date.accessioned2017-04-19T10:25:04Z-
dc.date.available2017-04-19T10:25:04Z-
dc.date.issued2016-
dc.identifier.issn1932-6203-
dc.identifier.uri10.1371/journal.pone.0158632ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13357-
dc.description.abstractThe effects of spiramycin on adipogenesis and high fat diet (HFD)-induced obesity were investigated. Potential mechanisms contributing to these effects were elucidated. The inhibitory effect of spiramycin on adipocyte differentiation was assessed using 3T3-L1 preadipocyte cells, in which several parameters involved in AMPK signal pathways and lipid metabolism were examined. To further investigate the pharmacological effects of spiramycin in vivo, we examined several obesity-related parameters in HFD-induced obese mice. Spiramycin significantly inhibited preadipocyte differentiation by attenuating intracellular lipid accumulation. Spiramycin also reduced the expression of adipogenic master regulators (PPARγ, C/EBPα, and SREBP1c) and their downstream target genes (FAS, aP2, and GLUT4) in 3T3-L1 cells. In addition, AMPK phosphorylation was increased by spiramycin treatment in 3T3-L1 cells during early differentiation. Notably, HFD-induced obese mice administered spiramycin showed substantial decreases in body weight gain, serum leptin levels, adipose tissue mass, and hepatic lipid accumulation. Moreover, the decreased levels of GPT and GOT in the serum indicated that spiramycin attenuated hepatic injury caused by HFD. Taken together, these results demonstrate for the first time that spiramycin effectively attenuates HFD-induced obesity and hepatic steatosis by inhibiting adipogenesis.-
dc.publisherPublic Library of Science-
dc.titleAnti-obesity effects of spiramycin in vitro and in vivo-
dc.title.alternativeAnti-obesity effects of spiramycin in vitro and in vivo-
dc.typeArticle-
dc.citation.titlePLoS One-
dc.citation.number7-
dc.citation.endPagee0158632-
dc.citation.startPagee0158632-
dc.citation.volume11-
dc.contributor.affiliatedAuthorMun-Ock Kim-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorJi Hee Choi-
dc.contributor.affiliatedAuthorTae Hyun Son-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.affiliatedAuthorHeung Joo Yuk-
dc.contributor.affiliatedAuthorSungchan Cho-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.affiliatedAuthorChang Woo Lee-
dc.contributor.affiliatedAuthorJinhyuk Lee-
dc.contributor.affiliatedAuthorSu Ui Lee-
dc.contributor.alternativeName김문옥-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName최지희-
dc.contributor.alternativeName손태현-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName육흥주-
dc.contributor.alternativeName조성찬-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName이창우-
dc.contributor.alternativeName이진혁-
dc.contributor.alternativeName이종길-
dc.contributor.alternativeName홍성태-
dc.contributor.alternativeName이수의-
dc.identifier.bibliographicCitationPLoS One, vol. 11, no. 7, pp. e0158632-e0158632-
dc.identifier.doi10.1371/journal.pone.0158632-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Nucleic Acid Therapeutics Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.