Methyltransferase ans demethylase profiling studies during brown adipocyte differentiation

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Methyltransferase ans demethylase profiling studies during brown adipocyte differentiation
Min Jeong Son; Won Kon KimKyoung Jin Oh; Anna Park; Da Som Lee; Baek Soo HanSang Chul LeeKwang-Hee Bae
Bibliographic Citation
BMB Reports, vol. 49, no. 7, pp. 388-393
Publication Year
Although brown adipose tissue is important with regard to energy balance, the molecular mechanism of brown adipocyte differentiation has not been extensively studied. Specifically, regulation factors at the level of protein modification are largely unknown. In this study, we examine the changes in the expression level of enzymes which are involved in protein lysine methylation during brown adipocyte differentiation. Several enzymes, in this case SUV420H2, PRDM9, MLL3 and JHDM1D, were found to be up-regulated. On the other hand, Set7/9 was significantly down-regulated. In the case of SUV420H2, the expression level increased sharply during brown adipocyte differentiation, whereas the expression of SUV420H2 was marginally enhanced during the white adipocyte differentiation. The knock-down of SUV420H2 caused the suppression of brown adipocyte differentiation, as compared to a scrambled control. These results suggest that SUV420H2, a methyltransferase, is involved in brown adipocyte differentiation, and that the methylation of protein lysine is important in brown adipocyte differentiation.
Brown adipocytesDemethylaseMethyltransferaseObesitySUV420H2
Korea Soc-Assoc-Inst
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Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Research on National Challenges > Biodefense Research Center > 1. Journal Articles
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