RGD peptide cell-surface display enhances the targeting and therapeutic efficacy of attenuated Salmonella-mediated cancer therapy

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dc.contributor.authorSeung Hwan Park-
dc.contributor.authorJ H Zheng-
dc.contributor.authorV H Nguyen-
dc.contributor.authorS N Jiang-
dc.contributor.authorD Y Kim-
dc.contributor.authorM Szardenings-
dc.contributor.authorJ H Min-
dc.contributor.authorY Hong-
dc.contributor.authorY E Choy-
dc.contributor.authorJ J Min-
dc.date.accessioned2017-04-19T10:25:42Z-
dc.date.available2017-04-19T10:25:42Z-
dc.date.issued2016-
dc.identifier.issn18387640-
dc.identifier.uri10.7150/thno.16135ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13376-
dc.description.abstractBacteria-based anticancer therapies aim to overcome the limitations of current cancer therapy by actively targeting and efficiently removing cancer. To achieve this goal, new approaches that target and maintain bacterial drugs at sufficient concentrations during the therapeutic window are essential. Here, we examined the tumor tropism of attenuated Salmonella typhimurium displaying the RGD peptide sequence (ACDCRGDCFCG) on the external loop of outer membrane protein A (OmpA). RGD-displaying Salmonella strongly bound to cancer cells overexpressing αvβ3, but weakly bound to αvβ3-negative cancer cells, suggesting the feasibility of displaying a preferential homing peptide on the bacterial surface. In vivo studies revealed that RGD-displaying Salmonellae showed strong targeting efficiency, resulting in the regression in αvβ3-overexpressing cancer xenografts, and prolonged survival of mouse models of human breast cancer (MDA-MB-231) and human melanoma (MDA-MB-435). Thus, surface engineering of Salmonellae to display RGD peptides increases both their targeting efficiency and therapeutic effect.-
dc.publisherIvyspring Int Publ-
dc.titleRGD peptide cell-surface display enhances the targeting and therapeutic efficacy of attenuated Salmonella-mediated cancer therapy-
dc.title.alternativeRGD peptide cell-surface display enhances the targeting and therapeutic efficacy of attenuated Salmonella-mediated cancer therapy-
dc.typeArticle-
dc.citation.titleTheranostics-
dc.citation.number10-
dc.citation.endPage1682-
dc.citation.startPage1672-
dc.citation.volume6-
dc.contributor.affiliatedAuthorSeung Hwan Park-
dc.contributor.alternativeName박승환-
dc.contributor.alternativeNameZheng-
dc.contributor.alternativeNameNguyen-
dc.contributor.alternativeNameJiang-
dc.contributor.alternativeName김동연-
dc.contributor.alternativeNameSzardenings-
dc.contributor.alternativeName민정현-
dc.contributor.alternativeName홍영진-
dc.contributor.alternativeName최현일-
dc.contributor.alternativeName민정준-
dc.identifier.bibliographicCitationTheranostics, vol. 6, no. 10, pp. 1672-1682-
dc.identifier.doi10.7150/thno.16135-
dc.subject.keywordSalmonella typhimurium-
dc.subject.keywordRGD peptide-
dc.subject.keywordbacteria-mediated cancer therapy-
dc.subject.keywordsurface display-
dc.subject.keywordbioluminescence imaging.-
dc.subject.localSalmonella typhimurium-
dc.subject.localRGD peptide-
dc.subject.localbacteria-mediated cancer therapy-
dc.subject.localsurface display-
dc.subject.localbioluminescence imaging.-
dc.subject.localBioluminescence imaging-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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