Chemical constituents and anti-inflammatory activity of the aerial parts of Curcuma longa = 강황 지상부의 화학성분 분석 및 항염증 활성

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Title
Chemical constituents and anti-inflammatory activity of the aerial parts of Curcuma longa = 강황 지상부의 화학성분 분석 및 항염증 활성
Author(s)
Dae Wook Kim; S M Lee; H S Woo; Ji Young Park; B S Ko; J D Heo; Young Bae RyuWoo Song Lee
Bibliographic Citation
Journal of Functional Foods, vol. 26, pp. 485-493
Publication Year
2016
Abstract
Curcuma longa is a perennial foodstuff plant that is utilized widely in Asia. Here, we evaluated the effects of extracts of the aerial parts of C. longa on inflammatory processes in RAW264.7 macrophage cells. Dried aerial parts of C. longa were extracted with methanol and partitioned successively with CH2Cl2 and n-BuOH. This n-BuOH fraction (0-40 μg/ml) significantly suppressed the lipopolysaccharide-mediated induction of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines. Western blotting found that the levels of nitric oxide synthase and cyclooxygenase-2 were also reduced in a concentration-dependent manner, in the absence of cytotoxicity. The major components present in this extract were isolated and chemically characterized using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry and nuclear magnetic resonance spectroscopy. Four flavonoids were identified: Quercetin 3-(2Gal-rhamnosyl-robinobioside) (1); Quercetin 3-rutinoside (2); Quercetin 3-rhamnosyl-(1→2)-rhamnoside (3); and Quercetin-3-O-rhamnoside (4).
Keyword
Anti-inflammatory activityCurcuma longaNMRUPLC-PDA-Q-TOF/MSAglycone flavonoids
ISSN
1756-4646
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jff.2016.08.026
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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