Identification of mycobacterial antigens in human urine by use of immunoglobulin g isolated from sera of patients with active pulmonary tuberculosis

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Title
Identification of mycobacterial antigens in human urine by use of immunoglobulin g isolated from sera of patients with active pulmonary tuberculosis
Author(s)
Sun Hee Kim; Nan Ee Lee; J S Lee; J H Shin; J Y Lee; Jeong Heon Ko; C L Chang; Yong Sam Kim
Bibliographic Citation
Journal of Clinical Microbiology, vol. 54, no. 6, pp. 1631-1637
Publication Year
2016
Abstract
Point-of-care (POC) diagnostic testing of tuberculosis (TB) is a tremendous unmet need. In this study, four urinary mycobacterial antigens were identified through two independent approaches using IgG capture and immunodepletion methods. Among these, ModC was validated by a multiple reaction monitoring (MRM) method. As expected, the biomarkers elevated the clinical validity of TB diagnosis when combined with preexisting markers.
ISSN
0095-1137
Publisher
Amer Soc Microb
DOI
http://dx.doi.org/10.1128/JCM.00236-16
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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