DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu Jin Kim | - |
dc.contributor.author | Hyeon Ju Kim | - |
dc.contributor.author | Geon Woo Kim | - |
dc.contributor.author | K Cho | - |
dc.contributor.author | S Takahashi | - |
dc.contributor.author | H Koshino | - |
dc.contributor.author | Won Gon Kim | - |
dc.date.accessioned | 2017-04-19T10:27:10Z | - |
dc.date.available | 2017-04-19T10:27:10Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | 10.1021/acs.jnatprod.6b00294 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13429 | - |
dc.description.abstract | Two new potent anti-Gram negative compounds, coralmycins A (1) and B (2), were isolated from cultures of the myxobacteria Corallococcus coralloides M23, together with another derivative (3) that was identified as the very recently reported cystobactamid 919-2. Their structures including the relative stereochemistry were elucidated by interpretation of spectroscopic, optical rotation, and CD data. The relative stereochemistry of 3 was revised to "S*R*" by NMR analysis. The antibacterial activity of 1 was most potent against Gram-negative pathogens, including Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumanii, and Klebsiella pneumoniae, with MICs of 0.1-4 μg/mL; these MICs were 4-10 and 40-100 times stronger than the antibacterial activities of 3 and 2, respectively. Thus, these data indicated that the β-methoxyasparagine unit and the hydroxy group of the benzoic acid unit were critical for antibacterial activity. | - |
dc.publisher | Amer Chem Soc | - |
dc.title | Isolation of coralmycins A and B, potent anti-Gram negative compounds from the myxobacteria Corallococcus coralloides M23 | - |
dc.title.alternative | Isolation of coralmycins A and B, potent anti-Gram negative compounds from the myxobacteria Corallococcus coralloides M23 | - |
dc.type | Article | - |
dc.citation.title | Journal of Natural Products | - |
dc.citation.number | 9 | - |
dc.citation.endPage | 2228 | - |
dc.citation.startPage | 2223 | - |
dc.citation.volume | 79 | - |
dc.contributor.affiliatedAuthor | Yu Jin Kim | - |
dc.contributor.affiliatedAuthor | Hyeon Ju Kim | - |
dc.contributor.affiliatedAuthor | Geon Woo Kim | - |
dc.contributor.affiliatedAuthor | Won Gon Kim | - |
dc.contributor.alternativeName | 김유진 | - |
dc.contributor.alternativeName | 김현주 | - |
dc.contributor.alternativeName | 김건우 | - |
dc.contributor.alternativeName | 조경윤 | - |
dc.contributor.alternativeName | Takahashi | - |
dc.contributor.alternativeName | Koshino | - |
dc.contributor.alternativeName | 김원곤 | - |
dc.identifier.bibliographicCitation | Journal of Natural Products, vol. 79, no. 9, pp. 2223-2228 | - |
dc.identifier.doi | 10.1021/acs.jnatprod.6b00294 | - |
dc.description.journalClass | Y | - |
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