Isolation of coralmycins A and B, potent anti-Gram negative compounds from the myxobacteria Corallococcus coralloides M23

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dc.contributor.authorYu Jin Kim-
dc.contributor.authorHyeon Ju Kim-
dc.contributor.authorGeon Woo Kim-
dc.contributor.authorK Cho-
dc.contributor.authorS Takahashi-
dc.contributor.authorH Koshino-
dc.contributor.authorWon Gon Kim-
dc.date.accessioned2017-04-19T10:27:10Z-
dc.date.available2017-04-19T10:27:10Z-
dc.date.issued2016-
dc.identifier.issn0163-3864-
dc.identifier.uri10.1021/acs.jnatprod.6b00294ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13429-
dc.description.abstractTwo new potent anti-Gram negative compounds, coralmycins A (1) and B (2), were isolated from cultures of the myxobacteria Corallococcus coralloides M23, together with another derivative (3) that was identified as the very recently reported cystobactamid 919-2. Their structures including the relative stereochemistry were elucidated by interpretation of spectroscopic, optical rotation, and CD data. The relative stereochemistry of 3 was revised to "S*R*" by NMR analysis. The antibacterial activity of 1 was most potent against Gram-negative pathogens, including Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumanii, and Klebsiella pneumoniae, with MICs of 0.1-4 μg/mL; these MICs were 4-10 and 40-100 times stronger than the antibacterial activities of 3 and 2, respectively. Thus, these data indicated that the β-methoxyasparagine unit and the hydroxy group of the benzoic acid unit were critical for antibacterial activity.-
dc.publisherAmer Chem Soc-
dc.titleIsolation of coralmycins A and B, potent anti-Gram negative compounds from the myxobacteria Corallococcus coralloides M23-
dc.title.alternativeIsolation of coralmycins A and B, potent anti-Gram negative compounds from the myxobacteria Corallococcus coralloides M23-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number9-
dc.citation.endPage2228-
dc.citation.startPage2223-
dc.citation.volume79-
dc.contributor.affiliatedAuthorYu Jin Kim-
dc.contributor.affiliatedAuthorHyeon Ju Kim-
dc.contributor.affiliatedAuthorGeon Woo Kim-
dc.contributor.affiliatedAuthorWon Gon Kim-
dc.contributor.alternativeName김유진-
dc.contributor.alternativeName김현주-
dc.contributor.alternativeName김건우-
dc.contributor.alternativeName조경윤-
dc.contributor.alternativeNameTakahashi-
dc.contributor.alternativeNameKoshino-
dc.contributor.alternativeName김원곤-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 79, no. 9, pp. 2223-2228-
dc.identifier.doi10.1021/acs.jnatprod.6b00294-
dc.description.journalClassY-
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Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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