Inhibition of the calcineurin pathway by two flavonoids isolated from Miliusa sinensis Finet & Gagnep.

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Title
Inhibition of the calcineurin pathway by two flavonoids isolated from Miliusa sinensis Finet & Gagnep.
Author(s)
Won-Jeong Lee; Jae Sun Moon; Young Tae Kim; T T Bach; D V Hai; Sung Uk Kim
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 26, no. 10, pp. 1696-1700
Publication Year
2016
Abstract
In order to discover plant-derived signaling pathway inhibitors with antifungal properties, a two-component screening system utilizing the calcineurin and Hog1 mitogen-activated protein kinase pathways responsible for the virulence networks of Cryptococcus neoformans was employed, owing to the counter-regulatory actions of these pathways. Of the 1,000 plant extracts tested, two bioactive compounds from Miliusa sinensis were found to act specifically on the calcineurin pathway of C. neoformans. These compounds, identified as pashanone and 5-hydroxy-6,7-dimethoxyflavanone, exhibited potent antifungal activities against various human pathogenic fungi with minimum inhibitory concentration values ranging from 4.0 to >128 μg/ml.
Keyword
Calcineurin pathwayCryptococcus neoformansMiliusa sinensis Finet & GagnepTwocomponent systemVirulence network
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4014/jmb.1605.05063
Type
Article
Appears in Collections:
Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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