Magnetic nanovector enabling miRNA-34a delivery for CD44 suppression with concurrent MR imaging

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Title
Magnetic nanovector enabling miRNA-34a delivery for CD44 suppression with concurrent MR imaging
Author(s)
H Lee; H O Kim; H Y Son; S B Lee; E Jang; B Kang; S Haam; Eun Kyung Lim; Y M Huh
Bibliographic Citation
Journal of Nanoscience and Nanotechnology, vol. 16, no. 12, pp. 12939-12946
Publication Year
2016
Abstract
We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF4) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a-conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy.
Keyword
CD44Gene deliveryMagnetic nanovectorMagnetic resonance imagingmiRNASurface modification
ISSN
1533-4880
Publisher
Amer Scientific Publishers
DOI
http://dx.doi.org/10.1166/jnn.2016.13797
Type
Article
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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