DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jina Kim | - |
dc.contributor.author | Yu Jin Lee | - |
dc.contributor.author | Jung Min Kim | - |
dc.contributor.author | So Young Lee | - |
dc.contributor.author | M A Bae | - |
dc.contributor.author | J H Ahn | - |
dc.contributor.author | Dong Cho Han | - |
dc.contributor.author | Byoung-Mog Kwon | - |
dc.date.accessioned | 2017-04-19T10:27:46Z | - |
dc.date.available | 2017-04-19T10:27:46Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1357-2725 | - |
dc.identifier.uri | 10.1016/j.biocel.2016.10.018 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13453 | - |
dc.description.abstract | PPAR agonists induced obesity in animal models as a side effect. Microarray experiments reveal thatPPAR agonist upregulates the expression of lipin-1 and this upregulation is correlated with the activityof the agonists. Lipin-1 induced by PPAR agonists decreased the levels of PPAR and ERK1/2 phospho-rylation through direct interaction with these proteins in 3T3-L1 cells. In PPAR agonist-treated 3T3-L1preadipocytes, the knockdown of lipin-1 expression by small interfering RNA inhibited the adipogenesisthat was induced by PPAR agonists. In contrast, PPAR 2 expression was increased, and lipid dropletswere accumulated in lipin-1-overexpressing 3T3-L1 adipocytes. Rosiglitazone (RGZ), a strong PPAR agonist, synergistically promoted PPAR dephosphorylation and adipogenesis in lipin-1-overexpressing3T3-L1 preadipocytes. Therefore, lipin-1 has dual functions as a transcriptional cofactor and phosphati-date phosphatase (PAP) in the differentiation of preadipocyte cells induced by strong PPAR agonists.In addition, the adipogenesis of 3T3-L1 cells was markedly upregulated by diacylglycerol (DAG), whichwas produced by lipin-1. Therefore, lipin-1 induction by PPAR agonists might be an important factorin understanding the biological mechanism of the agonists’ adverse effects, and this information maybe valuable in the development of type-2 diabetes mellitus (T2DM) therapeutics with reduced adverseeffects and greater tolerability. | - |
dc.publisher | Elsevier | - |
dc.title | PPARgamma agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPARgamma phosphatase = PPARgamma agonists와 비만과의 관련성 | - |
dc.title.alternative | PPARgamma agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPARgamma phosphatase | - |
dc.type | Article | - |
dc.citation.title | International Journal of Biochemistry & Cell Biology | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 66 | - |
dc.citation.startPage | 57 | - |
dc.citation.volume | 81 | - |
dc.contributor.affiliatedAuthor | Jina Kim | - |
dc.contributor.affiliatedAuthor | Yu Jin Lee | - |
dc.contributor.affiliatedAuthor | Jung Min Kim | - |
dc.contributor.affiliatedAuthor | So Young Lee | - |
dc.contributor.affiliatedAuthor | Dong Cho Han | - |
dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
dc.contributor.alternativeName | 김진아 | - |
dc.contributor.alternativeName | 이유진 | - |
dc.contributor.alternativeName | 김정민 | - |
dc.contributor.alternativeName | 이소영 | - |
dc.contributor.alternativeName | 배명애 | - |
dc.contributor.alternativeName | 안진희 | - |
dc.contributor.alternativeName | 한동초 | - |
dc.contributor.alternativeName | 권병목 | - |
dc.identifier.bibliographicCitation | International Journal of Biochemistry & Cell Biology, vol. 81, no. 1, pp. 57-66 | - |
dc.identifier.doi | 10.1016/j.biocel.2016.10.018 | - |
dc.subject.keyword | Lipin-1 | - |
dc.subject.keyword | PPAR | - |
dc.subject.keyword | Adipocytes | - |
dc.subject.keyword | PPAR agonists | - |
dc.subject.keyword | Phosphatase | - |
dc.subject.keyword | Obesity | - |
dc.subject.local | Lipin-1 | - |
dc.subject.local | PPAR | - |
dc.subject.local | Adipocyte | - |
dc.subject.local | adipocyte | - |
dc.subject.local | Adipocytes | - |
dc.subject.local | adipocytes | - |
dc.subject.local | PPAR agonists | - |
dc.subject.local | Phosphatases | - |
dc.subject.local | phosphatase | - |
dc.subject.local | Phosphatase | - |
dc.subject.local | Obesity | - |
dc.subject.local | obesity | - |
dc.description.journalClass | Y | - |
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