PPARgamma agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPARgamma phosphatase = PPARgamma agonists와 비만과의 관련성

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dc.contributor.authorJina Kim-
dc.contributor.authorYu Jin Lee-
dc.contributor.authorJung Min Kim-
dc.contributor.authorSo Young Lee-
dc.contributor.authorM A Bae-
dc.contributor.authorJ H Ahn-
dc.contributor.authorDong Cho Han-
dc.contributor.authorByoung-Mog Kwon-
dc.date.accessioned2017-04-19T10:27:46Z-
dc.date.available2017-04-19T10:27:46Z-
dc.date.issued2016-
dc.identifier.issn1357-2725-
dc.identifier.uri10.1016/j.biocel.2016.10.018ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13453-
dc.description.abstractPPAR agonists induced obesity in animal models as a side effect. Microarray experiments reveal thatPPAR agonist upregulates the expression of lipin-1 and this upregulation is correlated with the activityof the agonists. Lipin-1 induced by PPAR agonists decreased the levels of PPAR and ERK1/2 phospho-rylation through direct interaction with these proteins in 3T3-L1 cells. In PPAR agonist-treated 3T3-L1preadipocytes, the knockdown of lipin-1 expression by small interfering RNA inhibited the adipogenesisthat was induced by PPAR agonists. In contrast, PPAR 2 expression was increased, and lipid dropletswere accumulated in lipin-1-overexpressing 3T3-L1 adipocytes. Rosiglitazone (RGZ), a strong PPAR agonist, synergistically promoted PPAR dephosphorylation and adipogenesis in lipin-1-overexpressing3T3-L1 preadipocytes. Therefore, lipin-1 has dual functions as a transcriptional cofactor and phosphati-date phosphatase (PAP) in the differentiation of preadipocyte cells induced by strong PPAR agonists.In addition, the adipogenesis of 3T3-L1 cells was markedly upregulated by diacylglycerol (DAG), whichwas produced by lipin-1. Therefore, lipin-1 induction by PPAR agonists might be an important factorin understanding the biological mechanism of the agonists’ adverse effects, and this information maybe valuable in the development of type-2 diabetes mellitus (T2DM) therapeutics with reduced adverseeffects and greater tolerability.-
dc.publisherElsevier-
dc.titlePPARgamma agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPARgamma phosphatase = PPARgamma agonists와 비만과의 관련성-
dc.title.alternativePPARgamma agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPARgamma phosphatase-
dc.typeArticle-
dc.citation.titleInternational Journal of Biochemistry & Cell Biology-
dc.citation.number1-
dc.citation.endPage66-
dc.citation.startPage57-
dc.citation.volume81-
dc.contributor.affiliatedAuthorJina Kim-
dc.contributor.affiliatedAuthorYu Jin Lee-
dc.contributor.affiliatedAuthorJung Min Kim-
dc.contributor.affiliatedAuthorSo Young Lee-
dc.contributor.affiliatedAuthorDong Cho Han-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName김진아-
dc.contributor.alternativeName이유진-
dc.contributor.alternativeName김정민-
dc.contributor.alternativeName이소영-
dc.contributor.alternativeName배명애-
dc.contributor.alternativeName안진희-
dc.contributor.alternativeName한동초-
dc.contributor.alternativeName권병목-
dc.identifier.bibliographicCitationInternational Journal of Biochemistry & Cell Biology, vol. 81, no. 1, pp. 57-66-
dc.identifier.doi10.1016/j.biocel.2016.10.018-
dc.subject.keywordLipin-1-
dc.subject.keywordPPAR-
dc.subject.keywordAdipocytes-
dc.subject.keywordPPAR agonists-
dc.subject.keywordPhosphatase-
dc.subject.keywordObesity-
dc.subject.localLipin-1-
dc.subject.localPPAR-
dc.subject.localAdipocyte-
dc.subject.localadipocyte-
dc.subject.localAdipocytes-
dc.subject.localadipocytes-
dc.subject.localPPAR agonists-
dc.subject.localPhosphatases-
dc.subject.localphosphatase-
dc.subject.localPhosphatase-
dc.subject.localObesity-
dc.subject.localobesity-
dc.description.journalClassY-
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Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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