Stachybotrysin, an osteoclast differentiation inhibitor from the marine-derived fungus Stachybotrys sp. KCB13F013

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dc.contributor.authorJong Won Kim-
dc.contributor.authorSung-Kyun Ko-
dc.contributor.authorHye Min Kim-
dc.contributor.authorGun Hee Kim-
dc.contributor.authorSangkeun Son-
dc.contributor.authorGil Soo Kim-
dc.contributor.authorGui-Ja Hwang-
dc.contributor.authorEun Soo Jeon-
dc.contributor.authorKee Sun Shin-
dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorH Oh-
dc.contributor.authorKyung Ho Lee-
dc.contributor.authorNak Kyun Soung-
dc.contributor.authorD Hashizume-
dc.contributor.authorT Nogawa-
dc.contributor.authorS Takahashi-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorH Osada-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T10:27:57Z-
dc.date.available2017-04-19T10:27:57Z-
dc.date.issued2016-
dc.identifier.issn0163-3864-
dc.identifier.uri10.1021/acs.jnatprod.6b00641ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13456-
dc.description.abstractTwo new phenylspirodrimane derivatives, stachybotrysin (1) and stachybotrylactone B (2), were isolated from the cultures of the marine-derived fungus Stachybotrys sp. KCB13F013. The structures were determined by analyzing the spectroscopic data (1D and 2D NMR and MS) and chemical transformation, including the modified Mosher's method and single-crystal X-ray structure analysis. Compound 1 exhibited an inhibitory effect on osteoclast differentiation in bone marrow macrophage cells via suppressing the RANKL-induced activation of p-ERK, p-JNK, p-p38, c-Fos, and NFATc1.-
dc.publisherAmer Chem Soc-
dc.titleStachybotrysin, an osteoclast differentiation inhibitor from the marine-derived fungus Stachybotrys sp. KCB13F013-
dc.title.alternativeStachybotrysin, an osteoclast differentiation inhibitor from the marine-derived fungus Stachybotrys sp. KCB13F013-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number10-
dc.citation.endPage2708-
dc.citation.startPage2703-
dc.citation.volume79-
dc.contributor.affiliatedAuthorJong Won Kim-
dc.contributor.affiliatedAuthorSung-Kyun Ko-
dc.contributor.affiliatedAuthorHye Min Kim-
dc.contributor.affiliatedAuthorGun Hee Kim-
dc.contributor.affiliatedAuthorSangkeun Son-
dc.contributor.affiliatedAuthorGil Soo Kim-
dc.contributor.affiliatedAuthorGui-Ja Hwang-
dc.contributor.affiliatedAuthorEun Soo Jeon-
dc.contributor.affiliatedAuthorKee Sun Shin-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.affiliatedAuthorKyung Ho Lee-
dc.contributor.affiliatedAuthorNak Kyun Soung-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName김종원-
dc.contributor.alternativeName고성균-
dc.contributor.alternativeName김혜민-
dc.contributor.alternativeName김건희-
dc.contributor.alternativeName손상근-
dc.contributor.alternativeName김길수-
dc.contributor.alternativeName황귀자-
dc.contributor.alternativeName전은수-
dc.contributor.alternativeName신기선-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName오현철-
dc.contributor.alternativeName이경호-
dc.contributor.alternativeName성낙균-
dc.contributor.alternativeNameHashizume-
dc.contributor.alternativeNameNogawa-
dc.contributor.alternativeNameTakahashi-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeNameOsada-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 79, no. 10, pp. 2703-2708-
dc.identifier.doi10.1021/acs.jnatprod.6b00641-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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