A study on the evaluation of the PLGA-curcumin treated rat models for osteoporosis improvement using finite element analysis

Cited 0 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorS K Han-
dc.contributor.authorM J Sung-
dc.contributor.authorJ Ahn-
dc.contributor.authorJin Young Jeong-
dc.contributor.authorH S Yun-
dc.contributor.authorChang-Soo Lee-
dc.contributor.authorC Ko-
dc.date.accessioned2017-04-19T10:28:21Z-
dc.date.available2017-04-19T10:28:21Z-
dc.date.issued2017-
dc.identifier.issn02195194-
dc.identifier.uri10.1142/S0219519417500506ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13473-
dc.description.abstractOsteoporosis induced bone fracture is not limited to simple damage according to its fractured region and the age of the damaged person. Therefore, there has been more necessity to understand and study the biomechanical aspects of osteoporosis, and relevant research has actively been conducted. With the development of medical imaging technology, the reconstruction of CT images into a 3D model has been made possible, and it has been conducted to analyze 3-dimensionally and inhomogeneously distributed bone mineral density according to CT values. The 3D bone strength computational analysis based on 2D bone images utilized for evaluating the new treatment using the mixture of PLGA and curcumin for rat osteoporosis model. After the treatment, bone mineral density recovered by 65% compared to the osteoporosis model, moreover, bone strength improved by 113%. This study suggested that the limitations of conventional bone monitoring method using 2D bone images can be overcome by considering 3D bone computational analysis. It is considered that introducing the newly proposed Deformation Per Volume (DPW) and Stress Per Weight (SPW) can be also used as effective parameters to more accurately predict the change in bone stiffness.-
dc.publisherWorld Scientific Publ Co Pte Ltd-
dc.titleA study on the evaluation of the PLGA-curcumin treated rat models for osteoporosis improvement using finite element analysis-
dc.title.alternativeA study on the evaluation of the PLGA-curcumin treated rat models for osteoporosis improvement using finite element analysis-
dc.typeArticle-
dc.citation.titleJournal of Mechanics in Medicine and Biology-
dc.citation.number4-
dc.citation.endPage1750050-
dc.citation.startPage1750050-
dc.citation.volume17-
dc.contributor.affiliatedAuthorJin Young Jeong-
dc.contributor.affiliatedAuthorChang-Soo Lee-
dc.contributor.alternativeName한상규-
dc.contributor.alternativeName성미정-
dc.contributor.alternativeName안지윤-
dc.contributor.alternativeName정진영-
dc.contributor.alternativeName윤희숙-
dc.contributor.alternativeName이창수-
dc.contributor.alternativeName고철웅-
dc.identifier.bibliographicCitationJournal of Mechanics in Medicine and Biology, vol. 17, no. 4, pp. 1750050-1750050-
dc.identifier.doi10.1142/S0219519417500506-
dc.subject.keyword3D computational analysis-
dc.subject.keywordbone strength-
dc.subject.keywordOsteoporosis-
dc.subject.keywordrat osteoporosis model-
dc.subject.local3D computational analysis-
dc.subject.localbone strength-
dc.subject.localOsteoporosis-
dc.subject.localrat osteoporosis model-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.