Escherichia coli as a fatty acid and biodiesel factory: current challenges and future directions

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Title
Escherichia coli as a fatty acid and biodiesel factory: current challenges and future directions
Author(s)
Z Rahman; N Rashid; J Nawab; M Ilyas; Bong Hyun Sung; S C Kim
Bibliographic Citation
Environmental Science and Pollution Research, vol. 23, pp. 12007-12018
Publication Year
2016
Abstract
Biodiesel has received widespread attention as a sustainable, environment-friendly, and alternative source of energy. It can be derived from plant, animal, and microbial organisms in the form of vegetable oil, fats, and lipids, respectively. However, biodiesel production from such sources is not economically feasible due to extensive downstream processes, such as trans-esterification and purification. To obtain cost-effective biodiesel, these bottlenecks need to be overcome. Escherichia coli, a model microorganism, has the potential to produce biodiesel directly from ligno-cellulosic sugars, bypassing trans-esterification. In this process, E. coli is engineered to produce biodiesel using metabolic engineering technology. The entire process of biodiesel production is carried out in a single microbial cell, bypassing the expensive downstream processing steps. This review focuses mainly on production of fatty acid and biodiesel in E. coli using metabolic engineering approaches. In the first part, we describe fatty acid biosynthesis in E. coli. In the second half, we discuss bottlenecks and strategies to enhance the production yield. A complete understanding of current developments in E. coli-based biodiesel production and pathway optimization strategies would reduce production costs for biofuels and plant-derived chemicals
Keyword
BiodieselBiofuelFatty acidMetabolic engineeringMicrobial biofuel
ISSN
0944-1344
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s11356-016-6367-0
Type
Article
Appears in Collections:
Division of Biomaterials Research > Synthetic Biology and Bioengineering Research Center > 1. Journal Articles
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