DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mi-Kyung Lee | - |
dc.contributor.author | H E Kim | - |
dc.contributor.author | E B Park | - |
dc.contributor.author | J Lee | - |
dc.contributor.author | K H Kim | - |
dc.contributor.author | K Lim | - |
dc.contributor.author | S Yum | - |
dc.contributor.author | Y H Lee | - |
dc.contributor.author | S J Kang | - |
dc.contributor.author | J H Lee | - |
dc.contributor.author | B S Choi | - |
dc.date.accessioned | 2017-04-19T10:28:52Z | - |
dc.date.available | 2017-04-19T10:28:52Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | 10.1093/nar/gkw525 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13484 | - |
dc.description.abstract | Retinoic acid-inducible gene I (RIG-I) recognizes specific molecular patterns of viral RNAs for inducing type I interferon. The C-terminal domain (CTD) of RIG-I binds to double-stranded RNA (dsRNA) with the 5'-triphosphate (5'-PPP), which induces a conformational change in RIG-I to an active form. It has been suggested that RIG-I detects infection of influenza A virus by recognizing the 5'-triphosphorylated panhandle structure of the viral RNA genome. Influenza panhandle RNA has a unique structure with a sharp helical bending. In spite of extensive studies of how viral RNAs activate RIG-I, whether the structural elements of the influenza panhandle RNA confer the ability to activate RIG-I signaling has been poorly explored. Here, we investigated the dynamics of the influenza panhandle RNA in complex with RIG-I CTD using NMR spectroscopy and showed that the bending structure of the panhandle RNA negates the requirement of a 5'-PPP moiety for RIG-I activation. | - |
dc.publisher | Oxford Univ Press | - |
dc.title | Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate = 5' 말단 삼인산염과 관계없이 RIG-I를 활성화시키는 인플루엔자 A 바이러스의 팬핸들 RNA의 구조적 특성 | - |
dc.title.alternative | Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate | - |
dc.type | Article | - |
dc.citation.title | Nucleic Acids Research | - |
dc.citation.number | 17 | - |
dc.citation.endPage | 8416 | - |
dc.citation.startPage | 8407 | - |
dc.citation.volume | 44 | - |
dc.contributor.affiliatedAuthor | Mi-Kyung Lee | - |
dc.contributor.alternativeName | 이미경 | - |
dc.contributor.alternativeName | 김희은 | - |
dc.contributor.alternativeName | 박은별 | - |
dc.contributor.alternativeName | 이장현 | - |
dc.contributor.alternativeName | 김기훈 | - |
dc.contributor.alternativeName | 임경은 | - |
dc.contributor.alternativeName | 염서연 | - |
dc.contributor.alternativeName | 이영훈 | - |
dc.contributor.alternativeName | 강석조 | - |
dc.contributor.alternativeName | 이준화 | - |
dc.contributor.alternativeName | 최병석 | - |
dc.identifier.bibliographicCitation | Nucleic Acids Research, vol. 44, no. 17, pp. 8407-8416 | - |
dc.identifier.doi | 10.1093/nar/gkw525 | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.