Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate = 5' 말단 삼인산염과 관계없이 RIG-I를 활성화시키는 인플루엔자 A 바이러스의 팬핸들 RNA의 구조적 특성

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dc.contributor.authorMi-Kyung Lee-
dc.contributor.authorH E Kim-
dc.contributor.authorE B Park-
dc.contributor.authorJ Lee-
dc.contributor.authorK H Kim-
dc.contributor.authorK Lim-
dc.contributor.authorS Yum-
dc.contributor.authorY H Lee-
dc.contributor.authorS J Kang-
dc.contributor.authorJ H Lee-
dc.contributor.authorB S Choi-
dc.date.accessioned2017-04-19T10:28:52Z-
dc.date.available2017-04-19T10:28:52Z-
dc.date.issued2016-
dc.identifier.issn0305-1048-
dc.identifier.uri10.1093/nar/gkw525ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13484-
dc.description.abstractRetinoic acid-inducible gene I (RIG-I) recognizes specific molecular patterns of viral RNAs for inducing type I interferon. The C-terminal domain (CTD) of RIG-I binds to double-stranded RNA (dsRNA) with the 5'-triphosphate (5'-PPP), which induces a conformational change in RIG-I to an active form. It has been suggested that RIG-I detects infection of influenza A virus by recognizing the 5'-triphosphorylated panhandle structure of the viral RNA genome. Influenza panhandle RNA has a unique structure with a sharp helical bending. In spite of extensive studies of how viral RNAs activate RIG-I, whether the structural elements of the influenza panhandle RNA confer the ability to activate RIG-I signaling has been poorly explored. Here, we investigated the dynamics of the influenza panhandle RNA in complex with RIG-I CTD using NMR spectroscopy and showed that the bending structure of the panhandle RNA negates the requirement of a 5'-PPP moiety for RIG-I activation.-
dc.publisherOxford Univ Press-
dc.titleStructural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate = 5' 말단 삼인산염과 관계없이 RIG-I를 활성화시키는 인플루엔자 A 바이러스의 팬핸들 RNA의 구조적 특성-
dc.title.alternativeStructural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate-
dc.typeArticle-
dc.citation.titleNucleic Acids Research-
dc.citation.number17-
dc.citation.endPage8416-
dc.citation.startPage8407-
dc.citation.volume44-
dc.contributor.affiliatedAuthorMi-Kyung Lee-
dc.contributor.alternativeName이미경-
dc.contributor.alternativeName김희은-
dc.contributor.alternativeName박은별-
dc.contributor.alternativeName이장현-
dc.contributor.alternativeName김기훈-
dc.contributor.alternativeName임경은-
dc.contributor.alternativeName염서연-
dc.contributor.alternativeName이영훈-
dc.contributor.alternativeName강석조-
dc.contributor.alternativeName이준화-
dc.contributor.alternativeName최병석-
dc.identifier.bibliographicCitationNucleic Acids Research, vol. 44, no. 17, pp. 8407-8416-
dc.identifier.doi10.1093/nar/gkw525-
dc.description.journalClassY-
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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