Increased expression of herpes virus-encoded hsv1-miR-H18 and hsv2-miR-H9-5p in cancer-containing prostate tissue compared to that in benign prostate hyperplasia tissue

Cited 9 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorS J Yun-
dc.contributor.authorP Jeong-
dc.contributor.authorH W Kang-
dc.contributor.authorH K Shinn-
dc.contributor.authorY H Kim-
dc.contributor.authorC Yan-
dc.contributor.authorY K Choi-
dc.contributor.authorD Kim-
dc.contributor.authorD H Ryu-
dc.contributor.authorY S Ha-
dc.contributor.authorT H Kim-
dc.contributor.authorT G Kwon-
dc.contributor.authorJ M Kim-
dc.contributor.authorS H Suh-
dc.contributor.authorSeon-Kyu Kim-
dc.contributor.authorSeon-Young Kim-
dc.contributor.authorS T Kim-
dc.contributor.authorW T Kim-
dc.contributor.authorO J Lee-
dc.contributor.authorS K Moon-
dc.contributor.authorN H Kim-
dc.contributor.authorI Y Kim-
dc.contributor.authorJ Kim-
dc.contributor.authorH J Cha-
dc.contributor.authorY H Choi-
dc.contributor.authorE J Cha-
dc.contributor.authorW J Kim-
dc.date.accessioned2017-04-19T10:29:00Z-
dc.date.available2017-04-19T10:29:00Z-
dc.date.issued2016-
dc.identifier.issn20934777-
dc.identifier.uri10.5213/inj.1632552.276ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13488-
dc.description.abstractPurpose: Previously, we reported the presence of virus-encoded microRNAs (miRNAs) in the urine of prostate cancer (CaP) patients. In this study, we investigated the expression of two herpes virus-encoded miRNAs in prostate tissue. Methods: A total of 175 tissue samples from noncancerous benign prostatic hyperplasia (BPH), 248 tissue samples from patients with CaP and BPH, and 50 samples from noncancerous surrounding tissues from these same patients were analyzed for the expression of two herpes virus-encoded miRNAs by real-time polymerase chain reaction (PCR) and immunocytochemistry using nanoparticles as molecular beacons. Results: Real-time reverse transcription-PCR results revealed significantly higher expression of hsv1-miR-H18 and hsv2-miRH9- 5p in surrounding noncancerous and CaP tissues than that in BPH tissue (each comparison, P < 0.001). Of note, these miRNA were expressed equivalently in the CaP tissues and surrounding noncancerous tissues. Moreover, immunocytochemistry clearly demonstrated a significant enrichment of both hsv1-miR-H18 and hsv2-miR-H9 beacon-labeled cells in CaP and surrounding noncancerous tissue compared to that in BPH tissue (each comparison, P < 0.05 for hsv1-miR-H18 and hsv2- miR-H9). Conclusions: These results suggest that increased expression of hsv1-miR-H18 and hsv2-miR-H95p might be associated with tumorigenesis in the prostate. Further studies will be required to elucidate the role of these miRNAs with respect to CaP and herpes viral infections.-
dc.publisherSouth Korea-
dc.titleIncreased expression of herpes virus-encoded hsv1-miR-H18 and hsv2-miR-H9-5p in cancer-containing prostate tissue compared to that in benign prostate hyperplasia tissue-
dc.title.alternativeIncreased expression of herpes virus-encoded hsv1-miR-H18 and hsv2-miR-H9-5p in cancer-containing prostate tissue compared to that in benign prostate hyperplasia tissue-
dc.typeArticle-
dc.citation.titleInternational Neurourology Journal-
dc.citation.number0-
dc.citation.endPage130-
dc.citation.startPage122-
dc.citation.volume20-
dc.contributor.affiliatedAuthorSeon-Kyu Kim-
dc.contributor.affiliatedAuthorSeon-Young Kim-
dc.contributor.alternativeName윤석중-
dc.contributor.alternativeName정필두-
dc.contributor.alternativeName강호원-
dc.contributor.alternativeNameShinn-
dc.contributor.alternativeName김예환-
dc.contributor.alternativeNameYan-
dc.contributor.alternativeName최영기-
dc.contributor.alternativeName김동호-
dc.contributor.alternativeName류동희-
dc.contributor.alternativeName하윤석-
dc.contributor.alternativeName김태환-
dc.contributor.alternativeName권태균-
dc.contributor.alternativeName김정민-
dc.contributor.alternativeName서상헌-
dc.contributor.alternativeName김선규-
dc.contributor.alternativeName김선영-
dc.contributor.alternativeName김상태-
dc.contributor.alternativeName김원태-
dc.contributor.alternativeName이옥준-
dc.contributor.alternativeName문성권-
dc.contributor.alternativeName김남형-
dc.contributor.alternativeName김이삭이-
dc.contributor.alternativeName김자영-
dc.contributor.alternativeName차희재-
dc.contributor.alternativeName최영현-
dc.contributor.alternativeName차은종-
dc.contributor.alternativeName김원재-
dc.identifier.bibliographicCitationInternational Neurourology Journal, vol. 20, pp. 122-130-
dc.identifier.doi10.5213/inj.1632552.276-
dc.subject.keywordHerpesviridae-
dc.subject.keywordMicroRNAs-
dc.subject.keywordProstate Hyperplasia-
dc.subject.keywordProstate Neoplasms-
dc.subject.localHerpesviridae-
dc.subject.localMicroRNAs-
dc.subject.localMicroRNA-
dc.subject.localProstate Hyperplasia-
dc.subject.localProstate hyperplasia-
dc.subject.localProstate Neoplasms-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Korea Bioinformation Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.