Study of the UV light conversion of feruloyl amides from Portulaca oleracea and their inhibitory effect on IL-6-induced STAT3 activation

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dc.contributor.authorJoo Tae Hwang-
dc.contributor.authorYesol Kim-
dc.contributor.authorHyun Jae Jang-
dc.contributor.authorHyun-Mee Oh-
dc.contributor.authorC H Lim-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorMun Chual Rho-
dc.date.accessioned2017-04-19T10:29:31Z-
dc.date.available2017-04-19T10:29:31Z-
dc.date.issued2016-
dc.identifier.issn1420-3049-
dc.identifier.uri10.3390/molecules21070865ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13525-
dc.description.abstractTwo new feruloyl amides, N-cis-hibiscusamide (5) and (7′ S)-N-cis-feruloylnormetanephrine (9), and eight known feruloyl amides were isolated from Portulaca oleracea L. and the geometric conversion of the ten isolated feruloyl amides by UV light was verified. The structures of the feruloyl amides were determined based on spectroscopic data and comparison with literature data. The NMR data revealed that the structures of the isolated compounds showed cis/trans-isomerization under normal laboratory light conditions. Therefore, cis and trans-isomers of feruloyl amides were evaluated for their convertibility and stability by UV light of a wavelength of 254 nm. After 96 h of UV light exposure, 23.2%-35.0% of the cis and trans-isomers were converted to trans-isomers. Long-term stability tests did not show any significant changes. Among all compounds and conversion mixtures collected, compound 6 exhibited the strongest inhibition of IL-6-induced STAT3 activation in Hep3B cells, with an IC50 value of 0.2 μM. This study is the first verification of the conversion rates and an equilibrium ratio of feruloyl amides. These results indicate that this natural material might provide useful information for the treatment of various diseases involving IL-6 and STAT3.-
dc.publisherMDPI-
dc.titleStudy of the UV light conversion of feruloyl amides from Portulaca oleracea and their inhibitory effect on IL-6-induced STAT3 activation-
dc.title.alternativeStudy of the UV light conversion of feruloyl amides from Portulaca oleracea and their inhibitory effect on IL-6-induced STAT3 activation-
dc.typeArticle-
dc.citation.titleMolecules-
dc.citation.number0-
dc.citation.endPage865-
dc.citation.startPage865-
dc.citation.volume21-
dc.contributor.affiliatedAuthorJoo Tae Hwang-
dc.contributor.affiliatedAuthorYesol Kim-
dc.contributor.affiliatedAuthorHyun Jae Jang-
dc.contributor.affiliatedAuthorHyun-Mee Oh-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeName황주태-
dc.contributor.alternativeName김예솔-
dc.contributor.alternativeName장현재-
dc.contributor.alternativeName오현미-
dc.contributor.alternativeName임치환-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName노문철-
dc.identifier.bibliographicCitationMolecules, vol. 21, pp. 865-865-
dc.identifier.doi10.3390/molecules21070865-
dc.subject.keywordConversion study-
dc.subject.keywordFeruloyl amides-
dc.subject.keywordIL-6-
dc.subject.keywordPortulaca oleaceae L-
dc.subject.keywordSTAT3-
dc.subject.localConversion study-
dc.subject.localFeruloyl amides-
dc.subject.localIL6-
dc.subject.localinterukin -6-
dc.subject.localInterleukin-6 (IL-6)-
dc.subject.localIL-6-
dc.subject.localIl-6-
dc.subject.localinterleukin-6-
dc.subject.localinterleukin-6 (IL-6)-
dc.subject.localInterleukin-6-
dc.subject.localPortulaca oleracea L.-
dc.subject.localPortulaca oleracea-
dc.subject.localPortulaca oleracea L-
dc.subject.localPortulaca oleaceae L-
dc.subject.localSignal transducer and activator of transcription 3 (STAT3)-
dc.subject.localSignal transducer and activator of transcription-
dc.subject.localSignal transducer and activator of transcription 3 (Stat3)-
dc.subject.localSTAT 3-
dc.subject.localSTAT3-
dc.subject.localSignal transducer and activator of transcription 3-
dc.subject.localStat3-
dc.subject.localSignal transducer and activator of transcription factor 3 (STAT3)-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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