DC Field | Value | Language |
---|---|---|
dc.contributor.author | Y J Jeong | - |
dc.contributor.author | Jong Soon Kang | - |
dc.contributor.author | S I Lee | - |
dc.contributor.author | D M Son | - |
dc.contributor.author | Ji Eun Yun | - |
dc.contributor.author | J Y Baek | - |
dc.contributor.author | S K Kim | - |
dc.contributor.author | K Lee | - |
dc.contributor.author | S K Park | - |
dc.date.accessioned | 2017-04-19T10:29:44Z | - |
dc.date.available | 2017-04-19T10:29:44Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1792-1074 | - |
dc.identifier.uri | 10.3892/ol.2016.4852 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13527 | - |
dc.description.abstract | Triple negative breast cancer (TNBC), which does not express the progesterone, estrogen, or HER2/neu receptor, is aggressive and difficult to treat. Paclitaxel, a tubulin stabilizing agent, is one of the most frequently prescribed anticancer agents for breast cancers, including TNBC. Residual disease that occurs due to resistance or partial resistance of cancer cells in a tumor against anticancer agents is the most important issue in oncology. In the present study, when MDA-MB-231 cells, a TNBC cell line, were treated with 30 μM paclitaxel, a slightly higher concentration than its GI50 value, for 6 days, a small number of cells with different morphologies survived. Among the surviving cells, small round cells were isolated, cloned, and named MDA-MB-231-JYJ cells. MDA-MB-231-JYJ cells were observed to be highly proliferative and tumorigenic. In addition, signal transduction molecules involved in proliferation, survival, malignancy, or stemness of cancer cells, such as c-Src, c-Met, Notch 1, c-Myc, Sox2, Oct3/4, Nanog, and E-cadherin were highly expressed or activated. While further study is required, MDA-MB-231-JYJ cells appear to have some of the characteristics of cancer precursor cells. Although MDA-MB-231-JYJ cells were isolated from the cells that survived in the continuous presence of paclitaxel, they were not resistant to paclitaxel but developed resistance to dasatinib, a Bcr-Abl and Src kinase family inhibitor. The activated state of Src and Notch 1, and the expression levels of c-Myc and cyclins in MDA-MB-231-JYJ cells were less affected than MDA-MB-231 cells by the treatment of dasatinib, which may explain the resistance of MDA-MB-231-JYJ cells to dasatinib. These results suggest that cancer cells that become resistant to dasatinib during the process of paclitaxel therapy in patients may appear, and caution is required in the design of clinical trials using these two agents. | - |
dc.publisher | Spandidos Publ Ltd | - |
dc.title | Breast cancer cells evade paclitaxel-induced cell death by developing resistance to dasatinib | - |
dc.title.alternative | Breast cancer cells evade paclitaxel-induced cell death by developing resistance to dasatinib | - |
dc.type | Article | - |
dc.citation.title | Oncology Letters | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 2158 | - |
dc.citation.startPage | 2153 | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Jong Soon Kang | - |
dc.contributor.affiliatedAuthor | Ji Eun Yun | - |
dc.contributor.alternativeName | 정윤지 | - |
dc.contributor.alternativeName | 강종순 | - |
dc.contributor.alternativeName | 이수인 | - |
dc.contributor.alternativeName | 손동민 | - |
dc.contributor.alternativeName | 윤지은 | - |
dc.contributor.alternativeName | 백지영 | - |
dc.contributor.alternativeName | 김상겸 | - |
dc.contributor.alternativeName | 이기호 | - |
dc.contributor.alternativeName | 박성규 | - |
dc.identifier.bibliographicCitation | Oncology Letters, vol. 12, no. 3, pp. 2153-2158 | - |
dc.identifier.doi | 10.3892/ol.2016.4852 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Dasatinib | - |
dc.subject.keyword | Drug resistance | - |
dc.subject.keyword | Paclitaxel | - |
dc.subject.local | Breast cancer | - |
dc.subject.local | breast cancer | - |
dc.subject.local | Breast Cancer | - |
dc.subject.local | Dasatinib | - |
dc.subject.local | Drug resistance | - |
dc.subject.local | Drug-resistance | - |
dc.subject.local | drug-resistance | - |
dc.subject.local | drug resistance | - |
dc.subject.local | Paclitaxel | - |
dc.subject.local | paclitaxel | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.