The last ten years of advancements in plant-derived recombinant vaccines against hepatitis B = 식물-유래 간염 재조합 백신의 지난 10여년간 발전

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Title
The last ten years of advancements in plant-derived recombinant vaccines against hepatitis B = 식물-유래 간염 재조합 백신의 지난 10여년간 발전
Author(s)
Y H Joung; S H Park; Ki Beom Moon; Jae Heung JeonHye Sun ChoHyun Soon Kim
Bibliographic Citation
International Journal of Molecular Sciences, vol. 17, pp. 1715-1715
Publication Year
2016
Abstract
Disease prevention through vaccination is considered to be the greatest contribution to public health over the past century. Every year more than 100 million children are vaccinated with the standard World Health Organization (WHO)-recommended vaccines including hepatitis B (HepB). HepB is the most serious type of liver infection caused by the hepatitis B virus (HBV), however, it can be prevented by currently available recombinant vaccine, which has an excellent record of safety and effectiveness. To date, recombinant vaccines are produced in many systems of bacteria, yeast, insect, and mammalian and plant cells. Among these platforms, the use of plant cells has received considerable attention in terms of intrinsic safety, scalability, and appropriate modification of target proteins. Research groups worldwide have attempted to develop more efficacious plant-derived vaccines for over 30 diseases, most frequently HepB and influenza. More inspiring, approximately 12 plant-made antigens have already been tested in clinical trials, with successful outcomes. In this study, the latest information from the last 10 years on plant-derived antigens, especially hepatitis B surface antigen, approaches are reviewed and breakthroughs regarding the weak points are also discussed.
Keyword
AntigenHepatitis B virusMolecular farmingPlant edible vaccineRecombinant proteinVirus-like particles
ISSN
1422-0067
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ijms17101715
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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