DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chewook Lee | - |
dc.contributor.author | Do-Hyoung Kim | - |
dc.contributor.author | Si-Hyung Lee | - |
dc.contributor.author | J Su | - |
dc.contributor.author | Kyou Hoon Han | - |
dc.date.accessioned | 2017-04-19T10:30:15Z | - |
dc.date.available | 2017-04-19T10:30:15Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1225-8687 | - |
dc.identifier.uri | 10.5483/BMBRep.2016.49.8.021 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13554 | - |
dc.description.abstract | Human papillomavirus (HPV) is the major cause of cervical cancer, a deadly threat to millions of females. The early oncogene product (E7) of the high-risk HPV16 is the primary agent associated with HPV-related cervical cancers. In order to understand how E7 contributes to the transforming activity, we investigated the structural features of the flexible N-terminal region (46 residues) of E7 by carrying out N-15 heteronuclear NMR experiments and replica exchange molecular dynamics simulations. Several NMR parameters as well as simulation ensemble structures indicate that this intrinsically disordered region of E7 contains two transient (10-20% populated) helical pre-structured motifs that overlap with important target binding moieties such as an E2F-mimic motif and a pRb-binding LXCXE segment. Presence of such target-binding motifs in HPV16 E7 provides a reasonable explanation for its promiscuous target-binding behavior associated with its transforming activity. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Structural investigation on the intrinsically disordered N-terminal region of HPV16 E7 protein | - |
dc.title.alternative | Structural investigation on the intrinsically disordered N-terminal region of HPV16 E7 protein | - |
dc.type | Article | - |
dc.citation.title | BMB Reports | - |
dc.citation.number | 8 | - |
dc.citation.endPage | 436 | - |
dc.citation.startPage | 431 | - |
dc.citation.volume | 49 | - |
dc.contributor.affiliatedAuthor | Chewook Lee | - |
dc.contributor.affiliatedAuthor | Do-Hyoung Kim | - |
dc.contributor.affiliatedAuthor | Si-Hyung Lee | - |
dc.contributor.affiliatedAuthor | Kyou Hoon Han | - |
dc.contributor.alternativeName | 이제욱 | - |
dc.contributor.alternativeName | 김도형 | - |
dc.contributor.alternativeName | 이시형 | - |
dc.contributor.alternativeName | Su | - |
dc.contributor.alternativeName | 한규훈 | - |
dc.identifier.bibliographicCitation | BMB Reports, vol. 49, no. 8, pp. 431-436 | - |
dc.identifier.doi | 10.5483/BMBRep.2016.49.8.021 | - |
dc.subject.keyword | E7 oncoprotein | - |
dc.subject.keyword | Human papillomavirus (HPV) | - |
dc.subject.keyword | Intrinsically disordered protein (IDP) | - |
dc.subject.keyword | Molecular dynamics (MD) simulation | - |
dc.subject.keyword | Nuclear magnetic resonance (NMR) | - |
dc.subject.keyword | Pre-structured motif (PreSMo) | - |
dc.subject.local | E7 oncoprotein | - |
dc.subject.local | human papillomavirus (HPV) | - |
dc.subject.local | Human papillomavirus | - |
dc.subject.local | human paillomavirus(HPV) | - |
dc.subject.local | human papillomavirus | - |
dc.subject.local | Human papillomavirus (HPV) | - |
dc.subject.local | human papilloma virus (HPV) | - |
dc.subject.local | HPV | - |
dc.subject.local | intrinsically disordered protein | - |
dc.subject.local | Intrinsically disordered protein (IDP) | - |
dc.subject.local | Intrinsically disordered protein | - |
dc.subject.local | intrinsically disordered protein (IDP) | - |
dc.subject.local | Molecular dynamics (MD) simulation | - |
dc.subject.local | Molecular dynamics simulation | - |
dc.subject.local | Molecular dynamics simulations | - |
dc.subject.local | Molecular Dynamics (MD) simulations | - |
dc.subject.local | NMR | - |
dc.subject.local | nuclear magnetic resonance (Nmr) | - |
dc.subject.local | Nuclear magnetic resonance | - |
dc.subject.local | nuclear magnetic resonance | - |
dc.subject.local | Nuclear magnetic resonance (NMR) | - |
dc.subject.local | PreSMos (Pre-Structured Motifs) | - |
dc.subject.local | Pre-structured motif | - |
dc.subject.local | Prestructured motif (PreSMo) | - |
dc.subject.local | Pre-structured motif (PreSMo) | - |
dc.subject.local | PreSMo (Pre-Structured Motif) | - |
dc.subject.local | pre-structured motif | - |
dc.subject.local | pre-structured motifs (PreSMos) | - |
dc.subject.local | Pre-Structured Motif (PreSMo) | - |
dc.subject.local | PreSMo | - |
dc.subject.local | PreSMos (pre-structured motifs) | - |
dc.description.journalClass | Y | - |
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