Picroside II attenuates airway inflammation by downregulating the transcription factor GATA3 and Th2-related cytokines in a mouse model of HDM-induced allergic asthma

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dc.contributor.authorJin Choi-
dc.contributor.authorBo Gyong Choi-
dc.contributor.authorJin Seok Kim-
dc.contributor.authorJae Won Lee-
dc.contributor.authorHyun Ah Park-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorSu Ui Lee-
dc.contributor.authorK W Hwang-
dc.contributor.authorWoon Kee Yoon-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorHyun-Jun Lee-
dc.date.accessioned2017-04-19T10:30:22Z-
dc.date.available2017-04-19T10:30:22Z-
dc.date.issued2016-
dc.identifier.issn1932-6203-
dc.identifier.uri10.1371/journal.pone.0167098ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13558-
dc.description.abstractPicroside II isolated from Pseudolysimachion rotundum var. subintegrum has been used as traditional medicine to treat inflammatory diseases. In this study, we assessed whether picroside II has inhibitory effects on airway inflammation in a mouse model of house dust mite (HDM)-induced asthma. In the HDM-induced asthmatic model, picroside II significantly reduced inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), the levels of total immunoglobulin (Ig) E and HDM-specific IgE and IgG1 in serum, airway inflammation, and mucus hypersecretion in the lung tissues. ELISA analysis showed that picroside II down-regulated the levels of Th2-related cytokines (including IL-4, IL-5, and IL-13) and asthma-related mediators, but it up-regulated Th1-related cytokine, IFNγ in BALF. Picroside II also inhibited the expression of Th2 type cytokine genes and the transcription factor GATA3 in the lung tissues of HDM-induced mice. Finally, we demonstrated that picroside II significantly decreased the expression of GATA3 and Th2 cytokines in developing Th2 cells, consistent with in vivo results. Taken together, these results indicate that picroside II has protective effects on allergic asthma by reducing GATA3 expression and Th2 cytokine bias.-
dc.publisherPublic Library of Science-
dc.titlePicroside II attenuates airway inflammation by downregulating the transcription factor GATA3 and Th2-related cytokines in a mouse model of HDM-induced allergic asthma-
dc.title.alternativePicroside II attenuates airway inflammation by downregulating the transcription factor GATA3 and Th2-related cytokines in a mouse model of HDM-induced allergic asthma-
dc.typeArticle-
dc.citation.titlePLoS One-
dc.citation.number11-
dc.citation.endPagee0167098-
dc.citation.startPagee0167098-
dc.citation.volume11-
dc.contributor.affiliatedAuthorJin Choi-
dc.contributor.affiliatedAuthorBo Gyong Choi-
dc.contributor.affiliatedAuthorJin Seok Kim-
dc.contributor.affiliatedAuthorJae Won Lee-
dc.contributor.affiliatedAuthorHyun Ah Park-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorSu Ui Lee-
dc.contributor.affiliatedAuthorWoon Kee Yoon-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.affiliatedAuthorHyun-Jun Lee-
dc.contributor.alternativeName최진-
dc.contributor.alternativeName최보경-
dc.contributor.alternativeName김진석-
dc.contributor.alternativeName이재원-
dc.contributor.alternativeName박현아-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName이수의-
dc.contributor.alternativeName황광우-
dc.contributor.alternativeName윤원기-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이현준-
dc.identifier.bibliographicCitationPLoS One, vol. 11, no. 11, pp. e0167098-e0167098-
dc.identifier.doi10.1371/journal.pone.0167098-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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