Beneficial effects of pterocarpan-high soybean leaf extract on metabolic syndrome in overweight and obese Korean subjects: randomized controlled trial

Cited 10 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorR Ryu-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorY J Kim-
dc.contributor.authorJ Y Choi-
dc.contributor.authorS J Cho-
dc.contributor.authorE Y Kwon-
dc.contributor.authorU J Jung-
dc.contributor.authorHyeon Seon Ji-
dc.contributor.authorD H Shin-
dc.contributor.authorM S Choi-
dc.date.accessioned2017-04-19T10:30:26Z-
dc.date.available2017-04-19T10:30:26Z-
dc.date.issued2016-
dc.identifier.issn20726643-
dc.identifier.uri10.3390/nu8110734ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13573-
dc.description.abstractPterocarpans are known to have antifungal and anti-inflammatory properties. However, little is known about the changes in transcriptional profiles in response to a pterocarpan-high soybean leaf extract (PT). Therefore, this study investigated the effects of PT on blood glucose and lipid levels, as well as on the inflammation-related gene expression based on a peripheral blood mononuclear cells (PBMCs) mRNA sequencing analysis in Korean overweight and obese subjects with mild metabolic syndrome. The participants were randomly assigned to two groups and were administered either placebo (starch, 3 g/day) or PT (2 g/day) for 12 weeks. The PT intervention did not change body weight, body fat percentage and body mass index (BMI). However, PT significantly decreased the glycosylated hemoglobin (HbA1c), plasma glucose, free fatty acid, total cholesterol, and non-HDL cholesterol levels after 12 weeks. Furthermore, PT supplementation significantly lowered the homeostatic index of insulin resistance, as well as the plasma levels of inflammatory markers. Finally, the mRNA sequencing analysis revealed that PT downregulated genes related to immune responses. PT supplementation is beneficial for the improvement of metabolic syndrome by altering the fasting blood and plasma glucose, HbA1c, plasma lipid levels and inflammation-related gene expression in PBMCs.-
dc.publisherMDPI-
dc.titleBeneficial effects of pterocarpan-high soybean leaf extract on metabolic syndrome in overweight and obese Korean subjects: randomized controlled trial-
dc.title.alternativeBeneficial effects of pterocarpan-high soybean leaf extract on metabolic syndrome in overweight and obese Korean subjects: randomized controlled trial-
dc.typeArticle-
dc.citation.titleNutrients-
dc.citation.number0-
dc.citation.endPage734-
dc.citation.startPage734-
dc.citation.volume8-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeNameRyu-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName김예진-
dc.contributor.alternativeName최지영-
dc.contributor.alternativeName조수정-
dc.contributor.alternativeName권은영-
dc.contributor.alternativeName정운주-
dc.contributor.alternativeName지현선-
dc.contributor.alternativeName신동하-
dc.contributor.alternativeName최명숙-
dc.identifier.bibliographicCitationNutrients, vol. 8, pp. 734-734-
dc.identifier.doi10.3390/nu8110734-
dc.subject.keywordInflammation-
dc.subject.keywordMetabolic syndrome-
dc.subject.keywordMRNA sequencing-
dc.subject.keywordPBMCs-
dc.subject.keywordSoybean leaf-
dc.subject.localInflammation-
dc.subject.localMetabolic syndrome-
dc.subject.localMRNA sequencing-
dc.subject.localPBMCs-
dc.subject.localSoybean leaf-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.