Antiviral activity of Corylus heterophylla fisch against porcine epidemic diarrhea virus infection

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Title
Antiviral activity of Corylus heterophylla fisch against porcine epidemic diarrhea virus infection
Author(s)
J S Lee; Dur Han Kwon; H S Song; H J Choi; K Yoon
Bibliographic Citation
Journal of Bacteriology & Virology, vol. 46, no. 3, pp. 159-166
Publication Year
2016
Abstract
The porcine epidemic diarrhea virus (PEDV) has recently been shown to cause huge economic losses in the global pork industry. Our results demonstrated that the extract dose-dependently inhibited the replication of PEDV and reduced the visible cytopathic effect (CPE). Treatment with C. heterophylla Fisch extract resulted in marked reduction of PEDV-induced cytokine and chemokine expression. The antiviral activity of C. heterophylla Fisch extract on PEDV replication was found to be primarily exerted at the early stages after infection. Taken together, our data indicate that C. heterophylla Fisch extract may be a good therapeutic agent for use against PEDV and also a potential candidate to be evaluated against other human and animal coronaviruses.
Keyword
Antiviral activityCorylus heterophylla FischPorcine epidemic diarrhea virus (PEDV)
ISSN
1225-2344
Publisher
South Korea
DOI
http://dx.doi.org/10.4167/jbv.2016.46.3.159
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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