Construction of a minimal genome as a chassis for synthetic biology = 합성생물학을 위한 뼈대로써 최소 유전체 제작

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dc.contributor.authorBong Hyun Sung-
dc.contributor.authorD CHoe-
dc.contributor.authorS C Kim-
dc.contributor.authorB K Cho-
dc.date.accessioned2017-04-19T10:31:24Z-
dc.date.available2017-04-19T10:31:24Z-
dc.date.issued2016-
dc.identifier.issn0071-1365-
dc.identifier.uri10.1042/EBC20160024ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13645-
dc.description.abstractMicrobibal diversity and complexity pose challenges in understanding the voluminous genetic information produced from whole-genome sequences, bioinrofmatics and high-throughput'-omics' research. These challenges can be overcome by a core blueprint of a genome drawn with a minimal gene set, which is essential for life. Systems biologt and large-scale gene inactivation studies have estimated the number of essential genes to be ~300-500 in mant microbial genomes. On the basis of the essential gene set information, minimal-genime strains have been generated using sophisticated geno,e engineering techniques, such as genome reduction and chemocal genome synthesized genomes have just been con-structed. Some minimal genomes provide various desirable functions for bioindustry, such as improved genome stabilaty, increased transformation efficacy and improved production of biomaterials. The minimal genome as a chassis geno,e for synthetic biology can be used to construct custom-designed genomes for various practical and industrial applications.-
dc.publisherPortland Press Ltd-
dc.titleConstruction of a minimal genome as a chassis for synthetic biology = 합성생물학을 위한 뼈대로써 최소 유전체 제작-
dc.title.alternativeConstruction of a minimal genome as a chassis for synthetic biology-
dc.typeArticle-
dc.citation.titleEssays in Biochemistry-
dc.citation.number4-
dc.citation.endPage346-
dc.citation.startPage337-
dc.citation.volume60-
dc.contributor.affiliatedAuthorBong Hyun Sung-
dc.contributor.alternativeName성봉현-
dc.contributor.alternativeName최동희-
dc.contributor.alternativeName김선창-
dc.contributor.alternativeName조병관-
dc.identifier.bibliographicCitationEssays in Biochemistry, vol. 60, no. 4, pp. 337-346-
dc.identifier.doi10.1042/EBC20160024-
dc.description.journalClassY-
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Synthetic Biology and Bioengineering Research Institute > Synthetic Biology Research Center > 1. Journal Articles
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