DC Field | Value | Language |
---|---|---|
dc.contributor.author | M J Kwon | - |
dc.contributor.author | Sunhong Kim | - |
dc.contributor.author | M H Han | - |
dc.contributor.author | S B Lee | - |
dc.date.accessioned | 2017-04-19T10:31:25Z | - |
dc.date.available | 2017-04-19T10:31:25Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | 10.14348/molcells.2016.0233 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13649 | - |
dc.description.abstract | Afflicted neurons in various neurodegenerative diseases generally display diverse and complex pathological features before catastrophic occurrence of massive neuronal loss at the late stages of the diseases. This complex nature of neuronal pathophysiology inevitably implicates systemwide changes in basic cellular activities such as transcriptional controls and signal cascades, and so on, as a cause. Recently, as one of these systemwide cellular changes associated with neurodegenerative diseases, epigenetic changes caused by protein toxicity have begun to be highlighted. Notably, recent advances in related techniques including next-generation sequencing (NGS) and mass spectrometry enable us to monitor changes in the post-translational modifications (PTMs) of histone proteins and to link these changes in histone PTMs to the specific transcriptional changes. Indeed, epigenetic alterations and consequent changes in neuronal transcriptome are now begun to be extensively studied in neurodegenerative diseases including Alzheimer’s disease (AD). In this review, we will discuss details of our current understandings on epigenetic changes associated with two representative neurodegenerative diseases [AD and polyglutamine (polyQ) diseases] and further discuss possible future development of pharmaceutical treatment of the diseases through modulating these epigenetic changes. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Epigenetic changes in neurodegenerative diseases = 신경퇴행성 질환에서의 후성유전학적 변화 | - |
dc.title.alternative | Epigenetic changes in neurodegenerative diseases | - |
dc.type | Article | - |
dc.citation.title | Molecules and Cells | - |
dc.citation.number | 11 | - |
dc.citation.endPage | 789 | - |
dc.citation.startPage | 783 | - |
dc.citation.volume | 39 | - |
dc.contributor.affiliatedAuthor | Sunhong Kim | - |
dc.contributor.alternativeName | 권민지 | - |
dc.contributor.alternativeName | 김선홍 | - |
dc.contributor.alternativeName | 한명훈 | - |
dc.contributor.alternativeName | 이성배 | - |
dc.identifier.bibliographicCitation | Molecules and Cells, vol. 39, no. 11, pp. 783-789 | - |
dc.identifier.doi | 10.14348/molcells.2016.0233 | - |
dc.subject.keyword | Epigenetic changes | - |
dc.subject.keyword | Histone | - |
dc.subject.keyword | Neurodegenerative diseases | - |
dc.subject.keyword | Post-translational modifications | - |
dc.subject.local | Epigenetic change | - |
dc.subject.local | Epigenetic changes | - |
dc.subject.local | histone | - |
dc.subject.local | Histone | - |
dc.subject.local | neurodegenerative disease | - |
dc.subject.local | Neurodegenrative disease | - |
dc.subject.local | Neurodegenerative diseases | - |
dc.subject.local | Neurodegenerative disease | - |
dc.subject.local | Posttranslational modification | - |
dc.subject.local | posttranslational modification (PTM) | - |
dc.subject.local | Post-translational modifications | - |
dc.subject.local | posttranslational modification | - |
dc.subject.local | post-translational modification | - |
dc.subject.local | Posttranslational Modification | - |
dc.subject.local | Post-translational modification /PTM/ | - |
dc.description.journalClass | Y | - |
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