Complete genome sequence of Bacillus oceanisediminis 2691, a reservoir of heavy-metal resistance genes

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Title
Complete genome sequence of Bacillus oceanisediminis 2691, a reservoir of heavy-metal resistance genes
Author(s)
Jaejoon Jung; Haeyoung Jeong; Hyun Ju Kim; D W Lee; Sang Jun Lee
Bibliographic Citation
Marine Genomics, vol. 30, pp. 73-76
Publication Year
2016
Abstract
Ocean sediments are commonly subject to the pollution of various heavy metals. Intracellular heavy metal concentrations in marine microorganisms should be kept within allowable concentrations. Here, we report redundant heavy metal resistance related genes encoding heavy metal-sensing transcriptional regulators (i.e. cadC), heavy metal efflux pumps, and detoxifying enzymes in the complete genome sequence of Bacillus oceanisediminis 2691. By comparing CadC sequences of strain 2691 with those from other bacterial genomes, we demonstrated that each cadC gene located in the chromosome or plasmid of 2691 cells are similar to those of various near or distant microbes, which might shed light on evolutionary trajectories of redundant heavy metal resistance genes. In application aspects, these diverse heavy metal sensing genes can be harnessed as synthetic biological parts, modules, and devices for the development of heavy metal-specific biosensors. Heavy metal bioremediation technologies or platform cells can be also developed based on the marine genomic information of heavy metal resistance and/or detoxification genes in a bacterial isolate from ocean sediments
Keyword
Bacillus oceanisediminiscadCHeavy metalSedimentTranscriptional regulator
ISSN
1874-7787
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.margen.2016.07.002
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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