Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity = Thioredoxin-interacting protein에의한 조혈줄기세포의 노화 및 회춘 조절

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dc.contributor.authorHaiyoung Jung-
dc.contributor.authorDong Oh Kim-
dc.contributor.authorJae Eun Byun-
dc.contributor.authorWon Sam Kim-
dc.contributor.authorMi Jeong Kim-
dc.contributor.authorHae Young Song-
dc.contributor.authorY K Kim-
dc.contributor.authorDu-Kyeong Kang-
dc.contributor.authorYoung-Jun Park-
dc.contributor.authorTae-Don Kim-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorE J Choi-
dc.contributor.authorS H Min-
dc.contributor.authorIn Pyo Choi-
dc.date.accessioned2017-04-19T10:32:23Z-
dc.date.available2017-04-19T10:32:23Z-
dc.date.issued2016-
dc.identifier.issn2041-1723-
dc.identifier.uri10.1038/ncomms13674ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13669-
dc.description.abstractAgeing is a natural process in living organisms throughout their lifetime, and most elderly people suffer from ageing-associated diseases. One suggested way to tackle such diseases is to rejuvenate stem cells, which also undergo ageing. Here we report that the thioredoxin-interacting protein (TXNIP)-p38 mitogen-activated protein kinase (p38) axis regulates the ageing of haematopoietic stem cells (HSCs), by causing a higher frequency of long-term HSCs, lineage skewing, a decrease in engraftment, an increase in reactive oxygen species and loss of Cdc42 polarity. TXNIP inhibits p38 activity via direct interaction in HSCs. Furthermore, cell-penetrating peptide (CPP)-conjugated peptide derived from the TXNIP-p38 interaction motif inhibits p38 activity via this docking interaction. This peptide dramatically rejuvenates aged HSCs in vitro and in vivo. Our findings suggest that the TXNIP-p38 axis acts as a regulatory mechanism in HSC ageing and indicate the potent therapeutic potential of using CPP-conjugated peptide to rejuvenate aged HSCs.-
dc.publisherSpringer-Nature Pub Group-
dc.titleThioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity = Thioredoxin-interacting protein에의한 조혈줄기세포의 노화 및 회춘 조절-
dc.title.alternativeThioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity-
dc.typeArticle-
dc.citation.titleNature Communications-
dc.citation.number0-
dc.citation.endPage13674-
dc.citation.startPage13674-
dc.citation.volume7-
dc.contributor.affiliatedAuthorHaiyoung Jung-
dc.contributor.affiliatedAuthorDong Oh Kim-
dc.contributor.affiliatedAuthorJae Eun Byun-
dc.contributor.affiliatedAuthorWon Sam Kim-
dc.contributor.affiliatedAuthorMi Jeong Kim-
dc.contributor.affiliatedAuthorHae Young Song-
dc.contributor.affiliatedAuthorDu-Kyeong Kang-
dc.contributor.affiliatedAuthorYoung-Jun Park-
dc.contributor.affiliatedAuthorTae-Don Kim-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName정해용-
dc.contributor.alternativeName김동오-
dc.contributor.alternativeName변재은-
dc.contributor.alternativeName김원삼-
dc.contributor.alternativeName김미정-
dc.contributor.alternativeName송해영-
dc.contributor.alternativeName김영관-
dc.contributor.alternativeName강두경-
dc.contributor.alternativeName박영준-
dc.contributor.alternativeName김태돈-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName최은지-
dc.contributor.alternativeName민상현-
dc.contributor.alternativeName최인표-
dc.identifier.bibliographicCitationNature Communications, vol. 7, pp. 13674-13674-
dc.identifier.doi10.1038/ncomms13674-
dc.description.journalClassY-
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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