DC Field | Value | Language |
---|---|---|
dc.contributor.author | Haiyoung Jung | - |
dc.contributor.author | Dong Oh Kim | - |
dc.contributor.author | Jae Eun Byun | - |
dc.contributor.author | Won Sam Kim | - |
dc.contributor.author | Mi Jeong Kim | - |
dc.contributor.author | Hae Young Song | - |
dc.contributor.author | Y K Kim | - |
dc.contributor.author | Du-Kyeong Kang | - |
dc.contributor.author | Young-Jun Park | - |
dc.contributor.author | Tae-Don Kim | - |
dc.contributor.author | Suk Ran Yoon | - |
dc.contributor.author | Hee Gu Lee | - |
dc.contributor.author | E J Choi | - |
dc.contributor.author | S H Min | - |
dc.contributor.author | In Pyo Choi | - |
dc.date.accessioned | 2017-04-19T10:32:23Z | - |
dc.date.available | 2017-04-19T10:32:23Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | 10.1038/ncomms13674 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13669 | - |
dc.description.abstract | Ageing is a natural process in living organisms throughout their lifetime, and most elderly people suffer from ageing-associated diseases. One suggested way to tackle such diseases is to rejuvenate stem cells, which also undergo ageing. Here we report that the thioredoxin-interacting protein (TXNIP)-p38 mitogen-activated protein kinase (p38) axis regulates the ageing of haematopoietic stem cells (HSCs), by causing a higher frequency of long-term HSCs, lineage skewing, a decrease in engraftment, an increase in reactive oxygen species and loss of Cdc42 polarity. TXNIP inhibits p38 activity via direct interaction in HSCs. Furthermore, cell-penetrating peptide (CPP)-conjugated peptide derived from the TXNIP-p38 interaction motif inhibits p38 activity via this docking interaction. This peptide dramatically rejuvenates aged HSCs in vitro and in vivo. Our findings suggest that the TXNIP-p38 axis acts as a regulatory mechanism in HSC ageing and indicate the potent therapeutic potential of using CPP-conjugated peptide to rejuvenate aged HSCs. | - |
dc.publisher | Springer-Nature Pub Group | - |
dc.title | Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity = Thioredoxin-interacting protein에의한 조혈줄기세포의 노화 및 회춘 조절 | - |
dc.title.alternative | Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity | - |
dc.type | Article | - |
dc.citation.title | Nature Communications | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 13674 | - |
dc.citation.startPage | 13674 | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Haiyoung Jung | - |
dc.contributor.affiliatedAuthor | Dong Oh Kim | - |
dc.contributor.affiliatedAuthor | Jae Eun Byun | - |
dc.contributor.affiliatedAuthor | Won Sam Kim | - |
dc.contributor.affiliatedAuthor | Mi Jeong Kim | - |
dc.contributor.affiliatedAuthor | Hae Young Song | - |
dc.contributor.affiliatedAuthor | Du-Kyeong Kang | - |
dc.contributor.affiliatedAuthor | Young-Jun Park | - |
dc.contributor.affiliatedAuthor | Tae-Don Kim | - |
dc.contributor.affiliatedAuthor | Suk Ran Yoon | - |
dc.contributor.affiliatedAuthor | Hee Gu Lee | - |
dc.contributor.affiliatedAuthor | In Pyo Choi | - |
dc.contributor.alternativeName | 정해용 | - |
dc.contributor.alternativeName | 김동오 | - |
dc.contributor.alternativeName | 변재은 | - |
dc.contributor.alternativeName | 김원삼 | - |
dc.contributor.alternativeName | 김미정 | - |
dc.contributor.alternativeName | 송해영 | - |
dc.contributor.alternativeName | 김영관 | - |
dc.contributor.alternativeName | 강두경 | - |
dc.contributor.alternativeName | 박영준 | - |
dc.contributor.alternativeName | 김태돈 | - |
dc.contributor.alternativeName | 윤석란 | - |
dc.contributor.alternativeName | 이희구 | - |
dc.contributor.alternativeName | 최은지 | - |
dc.contributor.alternativeName | 민상현 | - |
dc.contributor.alternativeName | 최인표 | - |
dc.identifier.bibliographicCitation | Nature Communications, vol. 7, pp. 13674-13674 | - |
dc.identifier.doi | 10.1038/ncomms13674 | - |
dc.description.journalClass | Y | - |
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