Metabolic adaptation in obesity and type II diabetes: myokines, adipokines and hepatokines

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Title
Metabolic adaptation in obesity and type II diabetes: myokines, adipokines and hepatokines
Author(s)
Kyoung Jin Oh; Da Som Lee; Won Kon KimBaek Soo HanSang Chul LeeKwang-Hee Bae
Bibliographic Citation
International Journal of Molecular Sciences, vol. 18, pp. 8-8
Publication Year
2017
Abstract
Obesity and type II diabetes are characterized by insulin resistance in peripheral tissues. A high caloric intake combined with a sedentary lifestyle is the leading cause of these conditions. Whole-body insulin resistance and its improvement are the result of the combined actions of each insulin-sensitive organ. Among the fundamental molecular mechanisms by which each organ is able to communicate and engage in cross-talk are cytokines or peptides which stem from secretory organs. Recently, it was reported that several cytokines or peptides are secreted from muscle (myokines), adipose tissue (adipokines) and liver (hepatokines) in response to certain nutrition and/or physical activity conditions. Cytokines exert autocrine, paracrine or endocrine effects for the maintenance of energy homeostasis. The present review is focused on the relationship and cross-talk amongst muscle, adipose tissue and the liver as secretory organs in metabolic diseases.
Keyword
AdipokinesHepatokinesMyokinesObesityType II diabetes
ISSN
1422-0067
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ijms18010008
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Research on National Challenges > Biodefense Research Center > 1. Journal Articles
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