Ostalactones A-C, β- and ε-lactones with lipase inhibitory activity from the cultured basidiomycete Stereum ostrea

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Title
Ostalactones A-C, β- and ε-lactones with lipase inhibitory activity from the cultured basidiomycete Stereum ostrea
Author(s)
H S Kang; Jong-Pyung Kim
Bibliographic Citation
Journal of Natural Products, vol. 79, no. 12, pp. 3148-3151
Publication Year
2016
Abstract
Ostalactones A-C (1-3), three new β- and ε-lactone natural products, were isolated from the culture broth of the basidiomycete Stereum ostrea. The structures were elucidated by interpretation of HRFABMS and 1D and 2D NMR data. The structures of 1 and 2 are characterized by the presence of a β-lactone containing a fused 4/5 bicyclic core structure. Compound 3 possesses a 2-oxepinone ring system, which is likely to be a biosynthetic precursor of compounds 1 and 2. Ostalactones A (1) and B (2) displayed potent inhibitory activity against human pancreatic lipase.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.jnatprod.6b00647
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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