Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model

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dc.contributor.authorTae-Shin Park-
dc.contributor.authorYoung-Kyoung Ryu-
dc.contributor.authorHye-Yeon Park-
dc.contributor.authorJ Y Kim-
dc.contributor.authorJun Go-
dc.contributor.authorJung Ran Noh-
dc.contributor.authorYong-Hoon Kim-
dc.contributor.authorJung Hwan Hwang-
dc.contributor.authorDong Hee Choi-
dc.contributor.authorW K Oh-
dc.contributor.authorChul Ho Lee-
dc.contributor.authorKyoung Shim Kim-
dc.date.accessioned2017-04-19T10:33:06Z-
dc.date.available2017-04-19T10:33:06Z-
dc.date.issued2017-
dc.identifier.issn11073756-
dc.identifier.uri10.3892/ijmm.2016.2804ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13684-
dc.description.abstractHumulus japonicus Siebold and Zucc. (HJ) has traditionally been administered to patients with pulmonary disease, skin disease and hypertension in Korea, and it is considered to exert anti-inflammatory, antioxidant, antimicrobial and antimycobacterial effects. However, its effects against Alzheimer's disease (AD) have yet to be explored. Thus, this study was carried out to investigate whether HJ has a beneficial effect on the progression of AD in an animal model. A methanolic extract of HJ (500 mg/kg/day) was intragastrically administered to 5-month-old APP/PS1 transgenic (Tg-APP/PS1) mice for 2.5 months. Novel object recognition and Y-maze alteration tests were used to assess cognitive function, and an immunohistochemical assay was performed to assess amyloid β (Aβ)deposition, tau phosphorylation and gliosis. An in vitro assay using a microglial cell line was also performed to investigate the anti.inflammatory effects of HJ. Our results revealed that HJ significantly decreased the mRNA and protein expression levels of tumor necrosis factor-α (TNF.α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide in the microglial cell line. The administration of HJ for 2 months improved the cognitive function of Tg-APP/PS1 mice. HJ notably reduced the area occupied by Aβ and neurofibrillary tangles, and the number of activated astrocytes and microglia in the cortex of Tg-APP/PS1 mice. The findings of our study suggest that HJ has the therapeutic potential to inhibit the progression of AD and to improve cognitive deterioration in Tg-APP/PS1 mice.-
dc.publisherSpandidos Publ Ltd-
dc.titleHumulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model-
dc.title.alternativeHumulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model-
dc.typeArticle-
dc.citation.titleInternational Journal of Molecular Medicine-
dc.citation.number1-
dc.citation.endPage30-
dc.citation.startPage21-
dc.citation.volume39-
dc.contributor.affiliatedAuthorJung Ran Noh-
dc.contributor.affiliatedAuthorYong-Hoon Kim-
dc.contributor.affiliatedAuthorJung Hwan Hwang-
dc.contributor.affiliatedAuthorDong Hee Choi-
dc.contributor.affiliatedAuthorChul Ho Lee-
dc.contributor.affiliatedAuthorKyoung Shim Kim-
dc.contributor.alternativeName박태신-
dc.contributor.alternativeName유영경-
dc.contributor.alternativeName박혜연-
dc.contributor.alternativeName김재연-
dc.contributor.alternativeName고준-
dc.contributor.alternativeName노정란-
dc.contributor.alternativeName김용훈-
dc.contributor.alternativeName황정환-
dc.contributor.alternativeName최동희-
dc.contributor.alternativeName오원근-
dc.contributor.alternativeName이철호-
dc.contributor.alternativeName김경심-
dc.identifier.bibliographicCitationInternational Journal of Molecular Medicine, vol. 39, no. 1, pp. 21-30-
dc.identifier.doi10.3892/ijmm.2016.2804-
dc.subject.keywordAlzheimer's disease-
dc.subject.keywordCognition-
dc.subject.keywordHumulus japonicus-
dc.subject.keywordInflammation-
dc.subject.keywordα-amyloid plaque-
dc.subject.localAlzheimer's disease-
dc.subject.localAlzheimer’s disease-
dc.subject.localCognition-
dc.subject.localHumulus japonicus-
dc.subject.localInflammation-
dc.subject.localα-amyloid plaque-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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