Preferential use of minor codons in the translation initiation region of human genes = 인간유전자 번역 시작 부위 minor codon의 분포와 발현

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dc.contributor.authorJung Ho Park-
dc.contributor.authorM Kwon-
dc.contributor.authorY Yamaguchi-
dc.contributor.authorB L Firestein-
dc.contributor.authorJi Young Park-
dc.contributor.authorJi Eun Yun-
dc.contributor.authorJeong-Ook Yang-
dc.contributor.authorM Inouye-
dc.date.accessioned2017-04-19T10:33:19Z-
dc.date.available2017-04-19T10:33:19Z-
dc.date.issued2017-
dc.identifier.issn0340-6717-
dc.identifier.uri10.1007/s00439-016-1735-xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13694-
dc.description.abstractMore than 31,000 protein-coding sequences (CCDS) have been identified in the human genome. Here, we analyzed codon usage in all human CCDS and found that there is a preferential usage of minor codons for Ala (CGC), Pro (CCG), Ser (UCG), and Thr (ACG) in the initial 50-codon sequences of the CCDS. These codons, with consensus XCG sequences, are most infrequently used among their synonymous codons. Thus, the tRNA concentrations per codon are considered to be highest for the minor codons for Ala, Pro, Ser and Thr in comparison with other synonymous codons for each of them to enhance the translation efficiency. This suggests that human genes are regulated at the level of translation by preferentially using minor codons within the first 50 codons of the CCDS. This hypothesis was experimentally confirmed by comparing the expression of the luciferase gene encoded by minor codons with that encoded by major codons-
dc.publisherSpringer-
dc.titlePreferential use of minor codons in the translation initiation region of human genes = 인간유전자 번역 시작 부위 minor codon의 분포와 발현-
dc.title.alternativePreferential use of minor codons in the translation initiation region of human genes-
dc.typeArticle-
dc.citation.titleHuman Genetics-
dc.citation.number0-
dc.citation.endPage74-
dc.citation.startPage67-
dc.citation.volume136-
dc.contributor.affiliatedAuthorJung Ho Park-
dc.contributor.affiliatedAuthorJi Young Park-
dc.contributor.affiliatedAuthorJi Eun Yun-
dc.contributor.affiliatedAuthorJeong-Ook Yang-
dc.contributor.alternativeName박정호-
dc.contributor.alternativeName권문진-
dc.contributor.alternativeNameYamaguchi-
dc.contributor.alternativeNameFirestein-
dc.contributor.alternativeName박지영-
dc.contributor.alternativeName윤지은-
dc.contributor.alternativeName양정욱-
dc.contributor.alternativeNameInouye-
dc.identifier.bibliographicCitationHuman Genetics, vol. 136, pp. 67-74-
dc.identifier.doi10.1007/s00439-016-1735-x-
dc.description.journalClassY-
Appears in Collections:
Division of Bio Technology Innovation > Bio-Evaluation Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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