2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway

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dc.contributor.authorY Y Kim-
dc.contributor.authorI G Je-
dc.contributor.authorM J Kim-
dc.contributor.authorB C Kang-
dc.contributor.authorY A Choi-
dc.contributor.authorM C Baek-
dc.contributor.authorB Lee-
dc.contributor.authorJ K Choi-
dc.contributor.authorH R Park-
dc.contributor.authorT Y Shin-
dc.contributor.authorSoyoung Lee-
dc.contributor.authorSeung-Bin Yoon-
dc.contributor.authorSang-Rae Lee-
dc.contributor.authorD Khang-
dc.contributor.authorS H Kim-
dc.date.accessioned2017-08-29-
dc.date.available2017-08-29-
dc.date.issued2017-
dc.identifier.issn1671-4083-
dc.identifier.uri10.1038/aps.2016.112ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/16988-
dc.description.abstractMast cells are important effector cells in immunoglobulin (Ig) E-mediated allergic reactions such as asthma, atopic dermatitis and rhinitis. Vanillic acid, a natural product, has shown anti-oxidant and anti-inflammatory activities. In the present study, we investigated the anti-allergic inflammatory effects of ortho-vanillic acid (2-hydroxy-3-methoxybenzoic acid, o-VA) that was a derivative of vanillic acid isolated from Amomum xanthioides. In mouse anaphylaxis models, oral administration of o-VA (2, 10, 50 mg/kg) dose-dependently attenuated ovalbumin-induced active systemic anaphylaxis and IgE-mediated cutaneous allergic reactions such as hypothermia, histamine release, IgE production and vasodilation; administration of o-VA also suppressed the mast cell degranulator compound 48/80-induced anaphylaxis. In cultured mast cell line RBL-2H3 and isolated rat peritoneal mast cells in vitro, pretreatment with o-VA (1-100 μmol/L) dose-dependently inhibited DNP-HSA-induced degranulation of mast cells by decreasing the intracellular free calcium level, and suppressed the expression of pro-inflammatory cytokines TNF-α and IL-4. Pretreatment of RBL-2H3 cells with o-VA suppressed DNP-HSA-induced phosphorylation of Lyn, Syk, Akt, and the nuclear translocation of nuclear factor-κB. In conclusion, o-VA suppresses the mast cell-mediated allergic inflammatory response by blocking the signaling pathways downstream of high affinity IgE receptor (Fc?RI) on the surface of mast cells.-
dc.publisherSpringer-Nature Pub Group-
dc.title2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway-
dc.title.alternative2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway-
dc.typeArticle-
dc.citation.titleActa Pharmacologica Sinica-
dc.citation.number0-
dc.citation.endPage99-
dc.citation.startPage90-
dc.citation.volume38-
dc.contributor.affiliatedAuthorSoyoung Lee-
dc.contributor.affiliatedAuthorSeung-Bin Yoon-
dc.contributor.affiliatedAuthorSang-Rae Lee-
dc.contributor.alternativeName김연용-
dc.contributor.alternativeName제인규-
dc.contributor.alternativeName김민종-
dc.contributor.alternativeName강병철-
dc.contributor.alternativeName최영애-
dc.contributor.alternativeName백문창-
dc.contributor.alternativeName이병헌-
dc.contributor.alternativeName최진경-
dc.contributor.alternativeName박해란-
dc.contributor.alternativeName신태용-
dc.contributor.alternativeName이소영-
dc.contributor.alternativeName윤승빈-
dc.contributor.alternativeName이상래-
dc.contributor.alternativeName강동우-
dc.contributor.alternativeName김상현-
dc.identifier.bibliographicCitationActa Pharmacologica Sinica, vol. 38, pp. 90-99-
dc.identifier.doi10.1038/aps.2016.112-
dc.subject.keywordallergic inflammation-
dc.subject.keywordhigh affinity IgE receptor-
dc.subject.keywordhistamine-
dc.subject.keywordo-vanillic acid-
dc.subject.keywordpro-inflammatory cytokine-
dc.subject.keywordrat peritoneal mast cells-
dc.subject.keywordRBL-2H3 cells-
dc.subject.keywordtype I hypersensitivity-
dc.subject.localallergic inflammation-
dc.subject.localAllergic inflammation-
dc.subject.localhigh affinity IgE receptor-
dc.subject.localHistamine-
dc.subject.localhistamine-
dc.subject.localo-vanillic acid-
dc.subject.localproinflammatory cytokine-
dc.subject.localPro-inflammatory cytokine-
dc.subject.localProinflammatory cytokine-
dc.subject.localPro-inflammatory cytokines-
dc.subject.localProinflammatory cytokines-
dc.subject.localpro-inflammatory cytokine-
dc.subject.localrat peritoneal mast cells-
dc.subject.localRBL-2H3 cells-
dc.subject.localtype I hypersensitivity-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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