DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ji Young Park | - |
dc.contributor.author | Heung Joo Yuk | - |
dc.contributor.author | Hyung Won Ryu | - |
dc.contributor.author | Su Hwan Lim | - |
dc.contributor.author | Kyung Su Kim | - |
dc.contributor.author | K H Park | - |
dc.contributor.author | Young Bae Ryu | - |
dc.contributor.author | Woo Song Lee | - |
dc.date.accessioned | 2017-08-29 | - |
dc.date.available | 2017-08-29 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1475-6366 | - |
dc.identifier.uri | 10.1080/14756366.2016.1265519 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/17008 | - |
dc.description.abstract | he current study was designed to assess the inhibitory activity of Broussonetia papyrifera-derived polyphenols against 3-chymotrypsin-like and papain-like coronavirus cysteine proteases. The isolated compounds were broussochalcone B (1), broussochalcone A (2), 4-hydroxyisolonchocarpin (3), papyriflavonol A (4), 3'-(3-methylbut-2-enyl)-3',4,7-trihydroxyflavane (5), kazinol A (6), kazinol B (7), broussoflavan A (8), kazinol F (9), and kazinol J (10). All polyphenols were more potent against papain-like protease (PLpro) than against 3-chymotripsin-like protease (3CLpro); therefore, we investigated their structural features that were responsible for this selectivity. Compound 4 was the most potent inhibitor of PLpro with an IC50 value of 3.7?μM. The active compounds displayed kinetic behaviors, and the binding constants of their interaction with PLpro were determined from surface plasmon resonance analysis. Our results suggest B. papyrifera constituents as promising candidates for development into potential anti-coronaviral agents. | - |
dc.publisher | T&F (Taylor & Francis) | - |
dc.title | Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors | - |
dc.title.alternative | Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors | - |
dc.type | Article | - |
dc.citation.title | Journal of Enzyme Inhibition and Medicinal Chemistry | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 512 | - |
dc.citation.startPage | 504 | - |
dc.citation.volume | 32 | - |
dc.contributor.affiliatedAuthor | Ji Young Park | - |
dc.contributor.affiliatedAuthor | Heung Joo Yuk | - |
dc.contributor.affiliatedAuthor | Hyung Won Ryu | - |
dc.contributor.affiliatedAuthor | Su Hwan Lim | - |
dc.contributor.affiliatedAuthor | Kyung Su Kim | - |
dc.contributor.affiliatedAuthor | Young Bae Ryu | - |
dc.contributor.affiliatedAuthor | Woo Song Lee | - |
dc.contributor.alternativeName | 박지영 | - |
dc.contributor.alternativeName | 육흥주 | - |
dc.contributor.alternativeName | 류형원 | - |
dc.contributor.alternativeName | 임수환 | - |
dc.contributor.alternativeName | 김경수 | - |
dc.contributor.alternativeName | 박기훈 | - |
dc.contributor.alternativeName | 류영배 | - |
dc.contributor.alternativeName | 이우송 | - |
dc.identifier.bibliographicCitation | Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 32, no. 1, pp. 504-512 | - |
dc.identifier.doi | 10.1080/14756366.2016.1265519 | - |
dc.subject.keyword | Broussonetia papyrifera | - |
dc.subject.keyword | coronavirus | - |
dc.subject.keyword | papain-like protease | - |
dc.subject.keyword | polyphenol | - |
dc.subject.keyword | SARS | - |
dc.subject.local | Broussonetia papyrifera | - |
dc.subject.local | Coronavirus | - |
dc.subject.local | coronavirus | - |
dc.subject.local | papain-like protease | - |
dc.subject.local | Papain-like protease | - |
dc.subject.local | polyphenols | - |
dc.subject.local | Polyphenol | - |
dc.subject.local | Polyphenols | - |
dc.subject.local | polyphenol | - |
dc.subject.local | SARS | - |
dc.description.journalClass | Y | - |
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