Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors

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dc.contributor.authorJi Young Park-
dc.contributor.authorHeung Joo Yuk-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorSu Hwan Lim-
dc.contributor.authorKyung Su Kim-
dc.contributor.authorK H Park-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorWoo Song Lee-
dc.date.accessioned2017-08-29-
dc.date.available2017-08-29-
dc.date.issued2017-
dc.identifier.issn1475-6366-
dc.identifier.uri10.1080/14756366.2016.1265519ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17008-
dc.description.abstracthe current study was designed to assess the inhibitory activity of Broussonetia papyrifera-derived polyphenols against 3-chymotrypsin-like and papain-like coronavirus cysteine proteases. The isolated compounds were broussochalcone B (1), broussochalcone A (2), 4-hydroxyisolonchocarpin (3), papyriflavonol A (4), 3'-(3-methylbut-2-enyl)-3',4,7-trihydroxyflavane (5), kazinol A (6), kazinol B (7), broussoflavan A (8), kazinol F (9), and kazinol J (10). All polyphenols were more potent against papain-like protease (PLpro) than against 3-chymotripsin-like protease (3CLpro); therefore, we investigated their structural features that were responsible for this selectivity. Compound 4 was the most potent inhibitor of PLpro with an IC50 value of 3.7?μM. The active compounds displayed kinetic behaviors, and the binding constants of their interaction with PLpro were determined from surface plasmon resonance analysis. Our results suggest B. papyrifera constituents as promising candidates for development into potential anti-coronaviral agents.-
dc.publisherT&F (Taylor & Francis)-
dc.titleEvaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors-
dc.title.alternativeEvaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors-
dc.typeArticle-
dc.citation.titleJournal of Enzyme Inhibition and Medicinal Chemistry-
dc.citation.number1-
dc.citation.endPage512-
dc.citation.startPage504-
dc.citation.volume32-
dc.contributor.affiliatedAuthorJi Young Park-
dc.contributor.affiliatedAuthorHeung Joo Yuk-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorSu Hwan Lim-
dc.contributor.affiliatedAuthorKyung Su Kim-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName박지영-
dc.contributor.alternativeName육흥주-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName임수환-
dc.contributor.alternativeName김경수-
dc.contributor.alternativeName박기훈-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName이우송-
dc.identifier.bibliographicCitationJournal of Enzyme Inhibition and Medicinal Chemistry, vol. 32, no. 1, pp. 504-512-
dc.identifier.doi10.1080/14756366.2016.1265519-
dc.subject.keywordBroussonetia papyrifera-
dc.subject.keywordcoronavirus-
dc.subject.keywordpapain-like protease-
dc.subject.keywordpolyphenol-
dc.subject.keywordSARS-
dc.subject.localBroussonetia papyrifera-
dc.subject.localCoronavirus-
dc.subject.localcoronavirus-
dc.subject.localpapain-like protease-
dc.subject.localPapain-like protease-
dc.subject.localpolyphenols-
dc.subject.localPolyphenol-
dc.subject.localPolyphenols-
dc.subject.localpolyphenol-
dc.subject.localSARS-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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