NPS2143 inhibits MUC5AC and proinflammatory mediators in cigarette smoke extract (CSE)-stimulated human airway epithelial cells
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jae Won Lee | - |
| dc.contributor.author | Park Ji Won | - |
| dc.contributor.author | Ok-Kyoung Kwon | - |
| dc.contributor.author | H J Lee | - |
| dc.contributor.author | H G Jeong | - |
| dc.contributor.author | J H Kim | - |
| dc.contributor.author | Sei-Ryang Oh | - |
| dc.contributor.author | Kyung Seop Ahn | - |
| dc.date.accessioned | 2017-08-29 | - |
| dc.date.available | 2017-08-29 | - |
| dc.date.issued | 2017 | - |
| dc.identifier.issn | 0360-3997 | - |
| dc.identifier.uri | 10.1007/s10753-016-0468-2 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/17009 | - |
| dc.description.abstract | Mucus overproduction is a fundamental hallmark of COPD that is caused by exposure to cigarette smoke. MUC5AC is one of the main mucin genes expressed in the respiratory epithelium, and its transcriptional upregulation often correlates with increased mucus secretion. Calcium-sensing receptor (CaSR) antagonists have been reported to possess anti-inflammatory effects. The purpose of the present study was to investigate the protective role of NPS2143, a selective CaSR antagonist on cigarette smoke extract (CSE)-stimulated NCI-H292 mucoepidermoid human lung cells. Treatment of NPS2143 significantly inhibited the expression of MUC5AC in CSE-stimulated H292 cells. NPS2143 reduced the expression of MMP-9 in CSE-stimulated H292 cells. NPS2143 also decreased the release of proinflammatory cytokines such as IL-6 and TNF-α in CSE-stimulated H292 cells. Furthermore, NPS2143 attenuated the activation of MAPKs (JNK, p38, and ERK) and inhibited the nuclear translocation of NF-κB in CSE-stimulated H292 cells. These results indicate that NPS2143 had a therapeutic potential in COPD | - |
| dc.publisher | Springer | - |
| dc.title | NPS2143 inhibits MUC5AC and proinflammatory mediators in cigarette smoke extract (CSE)-stimulated human airway epithelial cells | - |
| dc.title.alternative | NPS2143 inhibits MUC5AC and proinflammatory mediators in cigarette smoke extract (CSE)-stimulated human airway epithelial cells | - |
| dc.type | Article | - |
| dc.citation.title | Inflammation | - |
| dc.citation.number | 1 | - |
| dc.citation.endPage | 194 | - |
| dc.citation.startPage | 184 | - |
| dc.citation.volume | 40 | - |
| dc.contributor.affiliatedAuthor | Jae Won Lee | - |
| dc.contributor.affiliatedAuthor | Park Ji Won | - |
| dc.contributor.affiliatedAuthor | Ok-Kyoung Kwon | - |
| dc.contributor.affiliatedAuthor | Sei-Ryang Oh | - |
| dc.contributor.affiliatedAuthor | Kyung Seop Ahn | - |
| dc.contributor.alternativeName | 이재원 | - |
| dc.contributor.alternativeName | 박지원 | - |
| dc.contributor.alternativeName | 권옥경 | - |
| dc.contributor.alternativeName | 이희재 | - |
| dc.contributor.alternativeName | 정혜광 | - |
| dc.contributor.alternativeName | 김재홍 | - |
| dc.contributor.alternativeName | 오세량 | - |
| dc.contributor.alternativeName | 안경섭 | - |
| dc.identifier.bibliographicCitation | Inflammation, vol. 40, no. 1, pp. 184-194 | - |
| dc.identifier.doi | 10.1007/s10753-016-0468-2 | - |
| dc.subject.keyword | chronic obstructive pulmonary disease | - |
| dc.subject.keyword | cigarette smoke | - |
| dc.subject.keyword | MAPKs | - |
| dc.subject.keyword | MUC5AC | - |
| dc.subject.keyword | NF-κB | - |
| dc.subject.keyword | NPS2143 | - |
| dc.subject.local | Chronic obstructive pulmonary disease | - |
| dc.subject.local | Chronic obstructive pulmonary disease (COPD) | - |
| dc.subject.local | chronic obstructive pulmonary disease | - |
| dc.subject.local | Pulmonary disease, chronic obstructive | - |
| dc.subject.local | Cigarette smoke | - |
| dc.subject.local | cigarette smoke | - |
| dc.subject.local | MAPK | - |
| dc.subject.local | MAPKs | - |
| dc.subject.local | MUC5AC | - |
| dc.subject.local | NFkappaB | - |
| dc.subject.local | NFκB | - |
| dc.subject.local | Nf-κB | - |
| dc.subject.local | Nf-κb | - |
| dc.subject.local | Nuclear factor (NF)-κB | - |
| dc.subject.local | Nuclear factor kappa B | - |
| dc.subject.local | Nuclear factor kappaB | - |
| dc.subject.local | Nuclear factor κB | - |
| dc.subject.local | Nuclear factor κB (NF-κB) | - |
| dc.subject.local | Nuclear factor-kappa B | - |
| dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
| dc.subject.local | Nuclear factor-kappaB | - |
| dc.subject.local | Nuclear factor-κB | - |
| dc.subject.local | Nuclear factor-κb | - |
| dc.subject.local | NF-kB | - |
| dc.subject.local | NF-kappa B | - |
| dc.subject.local | NF-kappaB | - |
| dc.subject.local | NF-ΚB | - |
| dc.subject.local | NF-κ B | - |
| dc.subject.local | NF-κB | - |
| dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
| dc.subject.local | nuclear factor kappa B | - |
| dc.subject.local | nuclear factor κB | - |
| dc.subject.local | nuclear factor-kappaB | - |
| dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
| dc.subject.local | nuclear factor-κB | - |
| dc.subject.local | nuclear factorκB | - |
| dc.subject.local | NPS 2143 | - |
| dc.subject.local | NPS2143 | - |
| dc.description.journalClass | Y | - |
- Appears in Collections:
- Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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