The cellular basis of dendrite pathology in neurodegenerative diseases = 신경퇴행성 질환에 대한 덴드라이트 병리의 세포학적 기반

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Title
The cellular basis of dendrite pathology in neurodegenerative diseases = 신경퇴행성 질환에 대한 덴드라이트 병리의 세포학적 기반
Author(s)
J H Kwon; Sun Hong Kim; S B Lee
Bibliographic Citation
BMB Reports, vol. 50, no. 1, pp. 5-11
Publication Year
2017
Abstract
One of the characteristics of the neurons that distinguishesthem from other cells is their complex and polarized structureconsisting of dendrites, cell body, and axon. The complexityand diversity of dendrites are particularly well recognized, andaccumulating evidences suggest that the alterations in thedendrite structure are associated with many neurodegenerativediseases. Given the importance of the proper dendriticstructures for neuronal functions, the dendrite pathologyappears to have crucial contribution to the pathogenesis ofneurodegenerative diseases. Nonetheless, the cellular andmolecular basis of dendritic changes in the neurodegenerativediseases remains largely elusive. Previous studies in normalcondition have revealed that several cellular components,such as local cytoskeletal structures and organelles locatedlocally in dendrites, play crucial roles in dendrite growth. Byreviewing what has been unveiled to date regarding dendritegrowth in terms of these local cellular components, we aim toprovide an insight to categorize the potential cellular basis thatcan be applied to the dendrite pathology manifested in manyneurodegenerative diseases.
Keyword
CytoskeletonDendrite pathologyGolgi outpostsMitochondriaNeurodegenerative diseases
ISSN
1225-8687
Publisher
South Korea
DOI
http://dx.doi.org/10.5483/BMBRep.2017.50.1.131
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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