Octaminomycins A and B, cyclic octadepsipeptides active against Plasmodium falciparum = 항말라리아 Octaminomycins A와 B

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dc.contributor.authorJun-Pil Jang-
dc.contributor.authorT Nogawa-
dc.contributor.authorY Futamura-
dc.contributor.authorT Shimizu-
dc.contributor.authorD Hashizume-
dc.contributor.authorS Yakahashi-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorH Osada-
dc.date.accessioned2017-08-29-
dc.date.available2017-08-29-
dc.date.issued2017-
dc.identifier.issn0163-3864-
dc.identifier.uri10.1021/acs.jnatprod.6b00758ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17014-
dc.description.abstractTwo new cyclic octadepsipeptides, octaminomycins A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces sp. RK85-270 based on Natural Products Plot screening. Their structures were elucidated on the basis of HRESIMS, 1D and 2D NMR spectroscopic data, and MS/MS experiments for sequence analysis. The absolute configurations of the constituent amino acid residues were determined by a combination of single-crystal X-ray diffraction and Marfey's methodology. Notably, octaminomycins A (1) and B (2) showed good in vitro antiplasmodial activity against chloroquine-sensitive as well as chloroquine-resistant strains with no cytotoxicity up to 30 μM. (Chemical Equation Presented)-
dc.publisherAmer Chem Soc-
dc.titleOctaminomycins A and B, cyclic octadepsipeptides active against Plasmodium falciparum = 항말라리아 Octaminomycins A와 B-
dc.title.alternativeOctaminomycins A and B, cyclic octadepsipeptides active against Plasmodium falciparum-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number1-
dc.citation.endPage140-
dc.citation.startPage134-
dc.citation.volume80-
dc.contributor.affiliatedAuthorJun-Pil Jang-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName장준필-
dc.contributor.alternativeNameNogawa-
dc.contributor.alternativeNameFutamura-
dc.contributor.alternativeNameShimizu-
dc.contributor.alternativeNameHashizume-
dc.contributor.alternativeNameYakahashi-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeNameOsada-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 80, no. 1, pp. 134-140-
dc.identifier.doi10.1021/acs.jnatprod.6b00758-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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