STAT5A-mediated NOX5-L expression promotes the proliferation and metastasis of breast cancer cells

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Title
STAT5A-mediated NOX5-L expression promotes the proliferation and metastasis of breast cancer cells
Author(s)
Sohee Dho; Jiyoung Kim; Kwang-Pyo LeeKwon Eun Soo; J C Lim; C J Kim; D Jeong; Ki Sun Kwon
Bibliographic Citation
Experimental Cell Research, vol. 351, no. 1, pp. 51-58
Publication Year
2017
Abstract
NADPH oxidase (NOX) generates reactive oxygen species (ROS) and has been suggested to mediate cell proliferation in some cancers. Here, we show that an increase in the expression of NOX5 long form (NOX5-L) is critical for tumor progression in breast tumor tissues. Immunostaining of clinical samples indicated that NOX5 was overexpressed in 41.1% of breast ductal carcinoma samples. NOX5-L depletion consistently suppressed cell proliferation, invasion, and migration in vitro. Antibody-mediated neutralization of NOX5-L attenuated tumor progression in a mouse xenograft model. Promoter analysis revealed that NOX5-L expression is regulated by STAT5A in breast cancer cells. Based on our novel findings, we suggest that inhibition of NOX5-L may be a promising therapeutic strategy that exerts anti-cancer effects via the modulation of ROS-mediated cell signaling.
Keyword
CancerNOX5-LROSSTAT5A
ISSN
0014-4827
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.yexcr.2016.12.020
Type
Article
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
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