Soy-leaf extract exerts atheroprotective effects via modulation of Kruppel-like factor 2 and adhesion molecules

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Title
Soy-leaf extract exerts atheroprotective effects via modulation of Kruppel-like factor 2 and adhesion molecules
Author(s)
J M Han; Hua Li; Moon-Hee Cho; Seung-Hwa Baek; Chul Ho LeeHo Yong ParkTae Sook Jeong
Bibliographic Citation
International Journal of Molecular Sciences, vol. 18, no. 2, pp. 373-373
Publication Year
2017
Abstract
Soy-leaf extracts exert their cardioprotective effects by inducing endothelium-dependent vasodilation in the arteries, and they favorably modulate the serum lipid profile. In this study, we investigated the atheroprotective effects of an ethanol extract of soy leaf (ESL) in human umbilical vein endothelial cells (HUVECs) and high-cholesterol diet (HCD)-fed low-density lipoprotein receptor deficient (LDLR?/?) mice. ESL induced the expression of Kruppel-like factor 2 (KLF2), an endothelial transcription factor, and endothelial nitric oxide synthase (eNOS), and suppressed the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) through moderate inflammatory signal activation, not only in tumor necrosis factor-α (TNF-α)-stimulated HUVECs but also in 7-ketocholesterol (7-KC)-stimulated HUVECs. ESL supplementation reduced aortic lesion formation in Western diet-fed LDLR?/? mice by 46% (p < 0.01) compared to the HCD group. ESL also markedly decreased the aortic expression levels of VCAM-1, ICAM-1, monocyte chemotactic protein-1 (MCP-1), TNF-α, IL-6, IL-1β, matrix metallopeptidase 9 (MMP-9), and fractalkine, while the expression of KLF2 was significantly increased. These results suggest that ESL supplementation has potential for preventing HCD-induced atherosclerosis effectively
Keyword
Adhesion moleculeAtherosclerosisInflammationKLF2Soy leaf
ISSN
1422-0067
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ijms18020373
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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