Tilianin inhibits MUC5AC expression mediated via down-regulation of EGFR-MEK-ERK-SP1 signaling pathway in NCI-H292 human airway cells

Cited 8 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorW Y Song-
dc.contributor.authorY S Song-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorJ T Hong-
dc.contributor.authorD Y Yoon-
dc.date.accessioned2017-08-29-
dc.date.available2017-08-29-
dc.date.issued2017-
dc.identifier.issn10177825-
dc.identifier.uri10.4014/jmb.1610.10012ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17037-
dc.description.abstractIn the human airway, mucus exists to protect the respiratory system as a primary barrier of the innate immune system. However, hyperexpressed mucus limits airflow, resulting in a decrease of lung function. Among more than 20 mucin family members, MUC5AC and MUC5B are major glycoproteins in human airway mucus. The epidermal growth factor receptor (EGFR) signaling pathway is one of the mechanisms of these mucins expression and specificity protein-1 (Sp1) transcription factor is the downstream signal of this pathway, playing pivotal roles in mucin expression. Even though there are some drugs for treating mucus hypersecretion, no drug has proven effects on humans. We found that the flavonoid tilianin regulated MUC5AC expression and also inhibited Sp1 phosphorylation. In this study, we investigated how tilianin would modulate EGFR signaling and regulate mucin production. In conclusion, tilianin inhibited MUC5AC expression mediated via modulating the EGFR-MEK-ERK-Sp1 signaling pathway in NCI-H292 human airway epithelial cells. This study may provide the basis for the novel treatment of mucus hypersecretion.-
dc.publisherSouth Korea-
dc.titleTilianin inhibits MUC5AC expression mediated via down-regulation of EGFR-MEK-ERK-SP1 signaling pathway in NCI-H292 human airway cells-
dc.title.alternativeTilianin inhibits MUC5AC expression mediated via down-regulation of EGFR-MEK-ERK-SP1 signaling pathway in NCI-H292 human airway cells-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number1-
dc.citation.endPage56-
dc.citation.startPage49-
dc.citation.volume27-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.alternativeName송원용-
dc.contributor.alternativeName송용석-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName홍진태-
dc.contributor.alternativeName윤도영-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 27, no. 1, pp. 49-56-
dc.identifier.doi10.4014/jmb.1610.10012-
dc.subject.keywordChronic obstructive pulmonary disease-
dc.subject.keywordEpidermal growth factor-
dc.subject.keywordMucin 5AC-
dc.subject.keywordSpecificity protein-1-
dc.subject.keywordTilianin-
dc.subject.localChronic obstructive pulmonary disease-
dc.subject.localEpidermal growth factor-
dc.subject.localMucin 5AC-
dc.subject.localSpecificity protein-1-
dc.subject.localSpecificity protein 1-
dc.subject.localTilianin-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.