DC Field | Value | Language |
---|---|---|
dc.contributor.author | S S Choi | - |
dc.contributor.author | Seung-Bin Yoon | - |
dc.contributor.author | Sang-Rae Lee | - |
dc.contributor.author | Sun-Uk Kim | - |
dc.contributor.author | Y J Cha | - |
dc.contributor.author | D Lee | - |
dc.contributor.author | S U Kim | - |
dc.contributor.author | Kyu Tae Chang | - |
dc.contributor.author | H J Lee | - |
dc.date.accessioned | 2017-08-29 | - |
dc.date.available | 2017-08-29 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0963-6897 | - |
dc.identifier.uri | 10.3727/096368916X692852 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/17039 | - |
dc.description.abstract | Despite the increasing importance of minipigs in biomedical research, there has been relatively little research concerning minipig-derived adult stem cells as a promising research tool that could be used to develop stem cell-based therapies. We first generated immortalized neural stem cells (iNSCs) from primary minipig olfactory bulb cells (pmpOBCs) and defined the characteristics of the cell line. Primary neural cells were prepared from minipig neonate olfactory bulbs and immortalized by infection with retrovirus carrying the v-myc gene. The minipig iNSCs (mpiNSCs) had normal karyotypes and expressed NSC-specific markers, including nestin, vimentin, Musashi1, and SOX2, suggesting a similarity to human NSCs. On the basis of the global gene expression profiles from the microarray analysis, neurogenesis-associated transcript levels were predominantly altered in mpiNSCs compared with pmpOBCs. These findings increase our understanding of minipig stem cells and contribute to the utility of mpiNSCs as resources for immortalized stem cell experiments. | - |
dc.publisher | Sage | - |
dc.title | Establishment and characterization of immortalized minipig neural stem cell line = 불멸화 미니돼지 신경줄기세포주의 확립 및 특성 분석 | - |
dc.title.alternative | Establishment and characterization of immortalized minipig neural stem cell line | - |
dc.type | Article | - |
dc.citation.title | Cell Transplantation | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 281 | - |
dc.citation.startPage | 271 | - |
dc.citation.volume | 26 | - |
dc.contributor.affiliatedAuthor | Seung-Bin Yoon | - |
dc.contributor.affiliatedAuthor | Sang-Rae Lee | - |
dc.contributor.affiliatedAuthor | Sun-Uk Kim | - |
dc.contributor.affiliatedAuthor | Kyu Tae Chang | - |
dc.contributor.alternativeName | 최성식 | - |
dc.contributor.alternativeName | 윤승빈 | - |
dc.contributor.alternativeName | 이상래 | - |
dc.contributor.alternativeName | 김선욱 | - |
dc.contributor.alternativeName | 차영주 | - |
dc.contributor.alternativeName | 이다이엘 | - |
dc.contributor.alternativeName | 김승업 | - |
dc.contributor.alternativeName | 장규태 | - |
dc.contributor.alternativeName | 이홍준 | - |
dc.identifier.bibliographicCitation | Cell Transplantation, vol. 26, pp. 271-281 | - |
dc.identifier.doi | 10.3727/096368916X692852 | - |
dc.subject.keyword | Immortalization | - |
dc.subject.keyword | Minipig | - |
dc.subject.keyword | Neural stem cells (NSCs) | - |
dc.subject.keyword | Olfactory bulb | - |
dc.subject.keyword | v-myc | - |
dc.subject.local | immortalization | - |
dc.subject.local | Immortalization | - |
dc.subject.local | Mini-pig | - |
dc.subject.local | minipig | - |
dc.subject.local | mini-pig | - |
dc.subject.local | Minipig | - |
dc.subject.local | neural stem cell | - |
dc.subject.local | Neural stem cell | - |
dc.subject.local | Neural stem cells | - |
dc.subject.local | Neural stem cells (NSCs) | - |
dc.subject.local | olfactory bulb | - |
dc.subject.local | Olfactory bulb | - |
dc.subject.local | v-myc | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.