Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation

Cited 32 time in scopus
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Title
Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
Author(s)
Yong Ryoul Yang; S Song; H Hwang; J H Jung; S J Kim; S Yoon; J H Jur; J I Park; C Lee; D Nam; Young Kyo Seo; J H Kim; H Rhim; P G Suh
Bibliographic Citation
Scientific Reports, vol. 7, pp. 44921-44921
Publication Year
2017
Abstract
O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga+/- mice which have an increased level of O-GlcNAcylation, and found that Oga+/- mice exhibited impaired spatial learning and memory. Consistent with this result, Oga+/- mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-O-GlcNAcylation in learning and memory
ISSN
2045-2322
Publisher
Springer-Nature Pub Group
Full Text Link
http://dx.doi.org/10.1038/srep44921
Type
Article
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
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